In a patient study of over 1,000 individuals with coronary artery disease (CAD), researchers have found that high levels of an enzyme called PLTP significantly increased the risk of heart attack in the subset of patients taking statins. While follow-up studies will be needed to tease out the exact connection between PLTP and statins, this connection does suggest levels of PLTP in the blood should be a consideration for potential statin treatment.
PLTP (phospholipid transferprotein) is involved in the metabolism of cholesterol-containing molecules like LDL and HDL, and therefore has been associated with atherosclerosis and heart disease. The exact role of PLTP in cardiovascular health remains debated, though, so Axel Schlitt and colleagues measured PLTP levels in 1,085 patients with CAD and then tracked how PLTP related to clinical outcome.
During the follow-up period (~5.1 years), 156 of the trial subjects suffered a fatal or non-fatal heart attack, including 47 individuals who were taking statins (out of 395 total statin patients). The researchers found that in this statin subset, PLTP levels were a significant predictor of cardiovascular outcome. In the total cohort, PLTP levels and outcome were not associated.
So while the statin patients experienced a lower overall rate of heart attack (12% vs. 15% -though the researchers note it's not especially significant, statistically), some individuals taking these drugs are at higher risk than normal. Schlitt and colleagues hypothesize that the high PLTP levels may blunt the beneficial effects of statins, though additional studies will certainly be needed.
From the article: "Phospholipid Transfer Protein Activity is a Risk Factor for subsequent Cardiovascular Events in Coronary Artery Disease Patients under Statin Therapy: the AtheroGene Study" by Axel Schlitt, Stefan Blankenberg, Christoph Bickel, Karl J. Lackner, Gunnar H. Heine, Michael Buerke, Karl Werdan, Lars Maegdefessel, Uwe Raaz, Hans J. Rupprecht, Munzel T, Xian-Cheng Jiang
Article link: http://www.jlr.org/cgi/content/abstract/M800414-JLR200v1
Corresponding Author: Axel Schlitt, MD, Department of Medicine III, Martin Luther-University, Germany; Phone: +49 345 557 2622, Email: axel.schlitt@medizin.uni-halle.de
The American Society for Biochemistry and Molecular Biology is a nonprofit scientific and educational organization with over 11,900 members in the United States and internationally. Most members teach and conduct research at colleges and universities. Others conduct research in various government laboratories, nonprofit research institutions and industry. The Society's student members attend undergraduate or graduate institutions.
Founded in 1906, the Society is based in Bethesda, Maryland, on the campus of the Federation of American Societies for Experimental Biology. The Society's purpose is to advance the science of biochemistry and molecular biology through publication of the Journal of Biological Chemistry, the Journal of Lipid Research, and Molecular and Cellular Proteomics, organization of scientific meetings, advocacy for funding of basic research and education, support of science education at all levels, and promoting the diversity of individuals entering the scientific work force.
For more information about ASBMB, see the Society's Web site at www.asbmb.org
Journal
Journal of Lipid Research