image: In patients with essential tremor, we found that neurons called Purkinje cells (PCs) in the cerebellum gradually loss a protein called GluRδ2. This protein loss leads to the overgrowth of cerebellar neuronal fibers, which generate too much synchronization and oscillations in the cerebellar neurons and thus cause tremor. PC: Purkinje cell; CF: climbing fiber of the cerebellum; EEG: electroencephalography. This material relates to a paper that appeared in the Jan. 15, 2020, issue of Science Translational Medicine, published by AAAS. The paper, by M.-K. Pan at National Taiwan University Hospital in Taipei City, Taiwan; and colleagues was titled, "Cerebellar oscillations driven by synaptic pruning deficits of cerebellar climbing fibers contribute to tremor pathophysiology." view more
Credit: Ming-Kai Pan, M.D., Ph.D. and Sheng-Han Kuo, M.D.