Jin Qiu, William B. J. Cafferty, Stephen B. McMahon, and Stephen W. N. Thompson
Regeneration in the CNS after spinal cord injury is limited because of obstacles such as glial scars and myelin-based inhibitory factors. On the other hand, axons in the PNS are much more resilient. This week, Qiu et al. provide evidence for Janus kinase (JAK)–signal transducer and activator of transcription (STAT) signaling downstream of the cytokines. The JAK2–STAT3 pathway appears to be growth-promoting after a peripheral nerve injury.
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