New York, NY [April 4, 2018]--A new study published today in the Journal of Pediatrics is the first to show that weight gain may have a negative impact on liver health in children as young as 8 years old. The study found that bigger waist circumference at age 3 raises the likelihood that by age 8, children will have markers for nonalcoholic fatty liver disease.
"With the rise in childhood obesity, we are seeing more kids with nonalcoholic fatty liver disease in our pediatric weight management practice," said Jennifer Woo Baidal, MD, MPH, assistant professor of pediatrics at Columbia University Vagelos College of Physicians and Surgeons and lead author of the paper. "Many parents know that obesity can lead to type 2 diabetes and other metabolic conditions, but there is far less awareness that obesity, even in young children, can lead to serious liver disease."
Nonalcoholic fatty liver disease occurs when too much fat accumulates in the liver and triggers inflammation, causing liver damage. The condition affects an estimated 80 million people in the U.S. and is the most common chronic liver condition in children and adolescents. While the disease is generally symptomless, progression of nonalcoholic fatty liver disease can lead to cirrhosis (scarring) of the liver and, in some instances, liver cancer.
Previous studies have focused on fatty liver disease in adolescents and young adults. In the current study, Woo Baidal and colleagues looked for fatty liver risk factors in younger children.
The researchers measured blood levels of a liver enzyme called ALT--elevated ALT is a marker for liver damage and can occur in individuals with nonalcoholic fatty liver disease and other conditions that affect the liver--in 635 children from Project Viva, an ongoing prospective study of women and children in Massachusetts.
By age 8, 23 percent of children in the study had elevated ALT levels. Children with a bigger waist circumference (a measure of abdominal obesity) at age 3 and those with greater gains in obesity measures between ages 3 and 8 were more likely to have elevated ALT. Approximately 35 percent of 8-year-olds with obesity had elevated ALT versus 20 percent of those with normal weight.
"Some clinicians measure ALT levels in at-risk children starting at around 10 years old, but our findings underscore the importance of acting earlier in a child's life to prevent excess weight gain and subsequent liver inflammation," says Woo Baidal, who is also director of pediatric weight management and a pediatric gastroenterologist in the Center for Adolescent Bariatric Surgery at NewYork-Presbyterian Morgan Stanley Children's Hospital. "Currently, the best way for kids and adults to combat fatty liver disease is to lose weight, by eating fewer processed foods and getting regular exercise. We urgently need better ways to screen, diagnose, prevent, and treat this disease starting in childhood."
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The study is titled, "Associations of Early to Mid-Childhood Adiposity with Elevated Mid-Childhood Alanine Aminotransferase Levels in the Project Viva Cohort." Additional authors are Erin Elbel (CUIMC), Joel Lavine (CUIMC), Sheryl Rifas-Shiman (Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA), Matthew Gillman (National Institutes of Health, Bethesda, MD, and Elsie Taveras (Massachusetts General Hospital, Boston, MA).
The study was supported by the National Institutes of Health (R25 DK096944, R01 HD034568, UG3 OD023286, KL2 TR000081, P30 DK040561, P30 DK092924, K24 HD069408, and K24 DK105989) and the Robert Wood Johnson Foundation.
The authors report no financial or other conflicts of interest.
Columbia University Irving Medical Center provides international leadership in basic, preclinical, and clinical research; medical and health sciences education; and patient care. The medical center trains future leaders and includes the dedicated work of many physicians, scientists, public health professionals, dentists, and nurses at the Vagelos College of Physicians and Surgeons, the Mailman School of Public Health, the College of Dental Medicine, the School of Nursing, the biomedical departments of the Graduate School of Arts and Sciences, and allied research centers and institutions. Columbia University Irving Medical Center is home to the largest medical research enterprise in New York City and State and one of the largest faculty medical practices in the Northeast. For more information, visit cumc.columbia.edu or columbiadoctors.org.
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Journal
The Journal of Pediatrics