Fetal exposure to radiation and the risk of childhood cancer: what is the likelihood of a risk?
A new study published in this week's PLoS Medicine aims to evaluate the possibility that exposure of a fetus to computed tomography or radionuclide imaging performed during pregnancy might increase subsequent risk of childhood cancer. The researchers concluded that despite the very large size of their study they were unable to exclude the possibility of a very slight risk, and advise that beta hCG testing (blood pregnancy test) should continue to be done in all potentially pregnant women before undergoing major radiodiagnostic testing. Similarly, use of lead apron shielding of the pelvic area of pregnant women is also recommended. The research was carried out by Joel Ray and colleagues from St. Michael's Hospital, Toronto, Canada, and colleagues.
The authors used an anonymized database for the whole province of Ontario, Canada (where universal health care is available to all residents) to link maternal radiation exposure to a subsequent malignancy in the child. Using this technique, the authors were able to follow up 1,835,517 mother-child pairs. In the entire dataset, 5,590 women were exposed to radiodiagnostic testing during pregnancy; amongst the children born to these exposed women, there were a total of four subsequent childhood cancers. There were 1,829,927 women in the unexposed group (who did not have radiodiagnostic imaging during pregnancy), and 2,539 cancers were found amongst the children born to these women. The rates of childhood cancer in exposed versus unexposed groups corresponds to a crude hazard ratio of 0.69. However, there was still substantial uncertainty in this study around the relative risk of malignancy following radiodiagnostic testing. The researchers estimated an "adjusted hazard ratio" for the risk to be 0.68, with confidence limits between 0.25 and 1.80. These confidence intervals (representing uncertainty) suggest that although the researchers did not find clear evidence for an increase in risk following imaging, they could not exclude the chance of a small increase, up to 1.8 times that in an unexposed pregnancy.
Given this possibility the authors recommend that radiodiagnostic testing should be performed in pregnancy under urgent or emergency situations, but that nonradiation-emitting imaging, such as MRI and ultrasonography, be considered first, when clinically appropriate. It should be emphasized that this study relates to the use of imaging modalities such as computed tomography (and other forms of radionuclide imaging), typically carried out to diagnose or exclude conditions encountered during an emergency, such as pulmonary embolism or stroke – and not the routine ultrasound scans done during pregnancy.
In an accompanying Perspective, Eduardo Franco and Guy-Anne Turgeon from McGill University, Montreal, Canada recommend that that an international consortium be formed to attempt to pool the data on exposure-risk associations from all available investigations to shed more light into this issue and assist policymakers in the future.
Funding: This study was funded by the Pediatric Oncology Group of Ontario (POGO). JGR and AG are supported by Canadian Institutes for Health Research New Investigator Award. This study was supported by the Institute for Clinical Evaluative Sciences (ICES), which is funded by the Ontario Ministry of Health and Long-Term Care (MOHLTC). The opinions, results, and conclusions reported in this paper are those of the authors and are independent from the funding sources. No endorsement by ICES or the Ontario MOHLTC is intended or should be inferred. No funding bodies had any role in the study design, data collection, analysis, decision to publish or preparation of the manuscript.
Competing Interests: The authors have declared that no competing interests exist.
Citation: Ray JG, Schull MJ, Urquia ML, You JJ, Guttmann A, et al. (2010) Major Radiodiagnostic Imaging in Pregnancy and the Risk of Childhood Malignancy: A Population-Based Cohort Study in Ontario. PLoS Med 7(9): e1000337. doi:10.1371/journal.pmed.1000337
IN YOUR COVERAGE PLEASE USE THIS URL TO PROVIDE ACCESS TO THE FREELY AVAILABLE PAPER: http://www.plosmedicine.org/article/info%3Adoi%2F10.1371%2Fjournal.pmed.1000337
PRESS-ONLY PREVIEW OF THE ARTICLE: http://www.plos.org/press/plme-07-09-ray.pdf
CONTACT:
Joel Ray
University of Toronto
Medicine
30 Bond St
Toronto, ON M5B 1W8
Canada
416 864-6060 Ext 6752
416 864-5485 (fax)
rayj@smh.toronto.on.ca
Julie Saccone
Senior Public Relations Specialist
St Michael's
SacconeJ@smh.ca
Related PLoS Medicine Perspective by Eduardo Franco and Guy-Anne Turgeon:
Funding: No specific funding was received for this article.
Competing interests: Eduardo Franco is on the Editorial Board of PLoS Medicine.
Citation: Franco EL, Turgeon G-A (2010) Radiodiagnostic Imaging in Pregnancy and the Risk of Childhood Malignancy: Raising the Bar. PLoS Med 7(9): e1000338. doi:10.1371/journal.pmed.1000338
IN YOUR COVERAGE PLEASE USE THIS URL TO PROVIDE ACCESS TO THE FREELY AVAILABLE PAPER: http://www.plosmedicine.org/article/info%3Adoi%2F10.1371%2Fjournal.pmed.1000338
PRESS-ONLY PREVIEW OF THE ARTICLE: http://www.plos.org/press/plme-07-09-franco.pdf
CONTACT:
Eduardo Franco
McGill University
Division of Cancer Epidemiology
546 Pine Avenue West
Montreal, QC H2W1S6
Canada
1-514-398-6032
1-514-398-5002 (fax)
eduardo.franco@mcgill.ca
Journal
PLOS Medicine