Arlington, Va. — A novel drug that mimics a naturally occurring molecule found in coffee and blueberries has been developed to treat radiation exposure. Charles R. Yates, Pharm.D., Ph.D., and colleagues Duane Miller, Ph.D., and Waleed Gaber, Ph.D., from the University of Tennessee Health Science Center and Baylor College of Medicine, show that application of this drug, starting 24 hours after radiation exposure, increases survival in animal models by three-fold compared to placebo.
Their work, which is funded through an NIH grant from the National Institute for Allergy and Infectious Diseases, is being presented at the 2012 American Association of Pharmaceutical Scientists (AAPS) Annual Meeting and Exposition, the world's largest pharmaceutical sciences meeting, in Chicago, Ill., Oct. 14 – 18.
"Development of drugs for individuals who are exposed to high-dose radiation in a public health emergency has been a priority since the 9/11 terrorist attacks," said Yates. "The ultimate goal is wide dissemination of non-invasive treatments after 24 hours of a mass casualty."
The high risk of vomiting after radiation exposure proves problematic for oral treatments, the most common non-invasive delivery method. Injectable medication is often proposed as the next line of defense, which comes with its own challenges. For example, training is often required for injections. To combat this problem, Yates and his team designed a new delivery system that can be applied directly to the skin, similar to an adhesive bandage.
"We are extremely proud to have exclusive rights to this exciting technology," said W. Shannon McCool, D.Ph., president & CEO of RxBio, the entity that has licensed the technology from the University of Tennessee Research Foundation.
This drug is also highly effective in models where radiation exposure is combined with skin wounds – a likely scenario in which people are exposed to shrapnel from dirty bombs or associated burn wounds.
The 2012 AAPS Annual Meeting and Exposition improves global health through advances in pharmaceutical sciences. The meeting features more than 90 programming sessions, including more than 50 symposia and roundtables.
AAPS is pleased to announce that our smartphone application is available at the 2012 AAPS Annual Meeting and Exposition. This application can assist meeting attendees with anything and everything they need to navigate the conference at their fingertips.
Editor's Note: All press must provide press credentials to attend this meeting. The deadline for online media registration is Oct. 5. After that date, media must register on-site. For media registration, please contact Kimberly Brown at BrownK@aaps.org or (703) 248-4772. To schedule an interview with Charles Yates or for any other press inquiry, please contact Hillarie Turner or Dana Korsen at aaps@ecius.net or 202-296-2002.
About AAPS:
The American Association of Pharmaceutical Scientists is a professional, scientific society of approximately 11,000 members employed in academia, industry, government and other research institutes worldwide. Founded in 1986, AAPS provides a dynamic international forum for the exchange of knowledge among scientists to serve the public and enhance their contributions to health. AAPS offers timely scientific programs, on-going education, information resources, opportunities for networking, and professional development. For more information, please visit www.aaps.org. Follow us on Twitter @AAPSComms; official Twitter hashtag for the meeting is: #AAPS2012.