Arrhythmia unraveled
Approximately half of all individuals implanted with pacemakers suffer from sinus node dysfunction. A new study of one such patient reveals a previously unknown mutation in the gene thought to primarily regulate the rhythmicity of the beating heart.
TITLE: Pacemaker channel dysfunction in a patient with sinus node disease
CONTACT:
Schulze-Bahr, Eric
Department of Cardiology, Hospital of the University of Münster, Münster, Germany.
Phone: 49-251-835-2982
E-mail: heart@uni-muenster.de
View the PDF of this article at: https://www.the-jci.org/press/16750.pdf
Throwing lupus for a loop
Lupus, an autoimmune disease primarily affecting women of childbearing age, is treated with steroids that often leave patients susceptible to infections, diabetes, and high blood pressure. A new study in non-human primates reports that treatment with specific antibodies can reverse established disease without the side effects associated with current steroid-based therapies.
TITLE: CD137 costimulatory T cell receptor engagement reverses acute disease in NZB x NZW F1 lupus-prone mice
AUTHOR CONTACT:
Robert Mittler
Emory University School of Medicine, Atlanta, Georgia, USA.
Phone: 404-727-9425
Fax: 404-727-8199
E-mail: rmittler@rmy.emory.edu
View the PDF of this article at: https://www.the-jci.org/press/17662.pdf
Programmed death of cardiac cells can cause heart failure
TITLE: A mechanistic role for cardiac myocyte apoptosis in heart failure
AUTHOR CONTACT:
Richard Kitsis
Albert Einstein College Of Medicine, Bronx, New York, USA.
Phone 1: 718-430-2609
Phone 2: 718-430-2000
Fax: 718-430-8991
E-mail: kitsis@aecom.yu.edu
View the PDF of this article at: https://www.the-jci.org/press/17664.pdf
RELATED ARTICLE:
TITLE: Activation of Mst1 causes dilated cardiomyopathy by stimulating apoptosis without compensatory ventricular myocyte hypertrophy
AUTHOR CONTACT:
Junichi Sadoshima
New Jersey Medical School and Hackensack University Medical Center, Newark, New Jersey, USA.
Phone: 973-972-8916
Fax: 973-972-8919
E-mail: sadoshju@umdnj.edu
View the PDF of this article at: https://www.the-jci.org/press/17459.pdf
ACCOMPANYING COMMENTARY:
A matter of life and death: cardiac myocyte apoptosis and regeneration
AUTHOR CONTACT:
Bernado Nadal-Ginard
New York Medical College, Valhalla, New York, USA.
Phone: 617-510-5769
E-mail: b_nadal-ginard@nymc.edu.
View the PDF of this commentary at: https://www.the-jci.org/press/18611.pdf
Host proteins prove to be antibactericidal all on their own
TITLE: Surfactant proteins A and D inhibit the growth of Gram-negative bacteria by increasing membrane permeability.
AUTHOR CONTACT:
Francis X. McCormack
University of Cincinnati School of Medicine, Cincinnati, Ohio, USA.
Phone: 513-558-0480
Fax: 513-558-0835
E-mail: frank.mccormack@uc.edu
View the PDF of this article at: https://www.the-jci.org/press/16889.pdf
ACCOMPANYING COMMENTARY:
Pulmonary surfactant: a front line of lung host defense
AUTHOR CONTACT:
Jo Rae Wright
Duke University School Of Medicine, Durham, North Carolina, USA.
Phone: 919-684-8040
Fax: 919-684-8106
E-mail: j.wright@cellbio.duke.edu
View the PDF of this commentary at: https://www.the-jci.org/press/18650.pdf
CD44's role in allergic airway inflammation and asthma
TITLE: A role for CD44 in an antigen-induced murine model of pulmonary eosinophilia
AUTHOR CONTACT:
Shigeki Katoh
Miyazaki Medical College, Kiyotake, Myazaki, Japan
Phone: 81-985-85-2965
Fax: 81-985-85-8305
E-mail: kshigeki@post1.miyazaki-med.ac.jp
View the PDF of this article at: https://www.the-jci.org/press/16583.pdf
ACCOMPANYING COMMENTARY:
CD44 -- a sticky target for asthma
AUTHOR CONTACT:
Marc E. Rothenberg
Children's Hospital Medical Center, Cincinnati, Ohio, USA.
Phone: 513-636-7210
Fax: 513-636-3310
E-mail: rothenberg@cchmc.org
View the PDF of this commentary at: https://www.the-jci.org/press/18392.pdf
New path to therapy for pulmonary hypertension
Current treatments for pulmonary hypertension are only capable of delaying progression of the disease and lung transplantation is ultimately necessary. Researchers have now found that mice deficient of a factor known as HIF-2a are protected against pulmonary hypertension, indicating that pharmaceutical inhibitors of this factor may be useful in the prevention or reduction of pulmonary hypertension.
TITLE: Heterozygous deficiency of hypoxia-inducible factor-2a protects mice against pulmonary hypertension and right ventricular dysfunction during prolonged hypoxia
AUTHOR CONTACT:
Peter Carmeliet
KU Leuven, Flanders Interuniversity Institute of Biotechnology, Leuven, Belgium.
Phone 1: 32-16-345-772
Phone 2: 32-16-345-780
Fax: 32-16-345-990
E-mail: peter.carmeliet@med.kuleuven.ac.be
View the PDF of this article at: https://www.the-jci.org/press/15496.pdf
At the heart of hypertrophy
TITLE: Targeted inhibition of p38 MAPK promotes hypertrophic cardiomyopathy through upregulation of calcineurin-NFAT signaling
AUTHOR CONTACT:
Jeffrey D. Molkentin
Children's Hospital Medical Center, Cincinnati, Ohio, USA.
Phone: 513-636-3557
Fax: 513-636-5958
E-mail: MolkJ0@CHMCC.org
View the PDF of this article at: https://www.the-jci.org/press/17295.pdf
Alternative strategy for tumor immunotherapy
TITLE: Antigenic drift as a mechanism for tumor evasion of destruction by cytolytic T lymphocytes
AUTHOR CONTACT:
Yang Liu
Ohio State University Medical Center, Columbus, Ohio, USA.
Phone: 614-292-3054
Fax: 614-688-8152
E-mail: liu-3@medctr.osu.edu
View the PDF of this article at: https://www.the-jci.org/press/17656.pdf
Cardiac muscle gets excited
TITLE: Functional role of inward rectifier current in heart probed by Kir2.1 overexpression and dominant-negative suppression
AUTHOR CONTACT:
Bradley Nuss
University of Maryland School of Medicine, Baltimore, Maryland, USA.
Phone: 410-706-1134
Fax: 410-706-8610
E-mail: bnuss@medicine.umaryland.edu
View the PDF of this article at: https://www.the-jci.org/press/17959.pdf
Distinguishing self from non-self in transplant rejection
TITLE: Critical role of Toll-like receptor signal adaptor protein MyD88 in acute allograft rejection
AUTHOR CONTACT:
Daniel Goldstein
Yale University, New Haven, Connecticut, USA.
Phone: 203-785-3271
Fax: 203-737-1801
E-mail: daniel.goldstein@yale.edu
View the PDF of this article at: https://www.the-jci.org/press/17573.pdf
The cardiovascular effects of cholesterol carriers and estrogen
TITLE: HDL-associated estradiol stimulates endothelial NO synthase and vasodilation in an SR-BI–dependent manner
AUTHOR CONTACT:
Eric Smart
University of Kentucky, Lexington, Kentucky, USA.
Phone: 859-323-6412
Fax: 859-323-1070
E-mail: ejsmart@uky.edu
View the PDF of this article at: https://www.the-jci.org/press/16777.pdf
Glucose sensing and signaling
TITLE: GLUT4, AMP kinase, but not the insulin receptor, are required for hepatoportal glucose sensor–stimulated muscle glucose utilization
AUTHOR CONTACT:
Bernard Thorens
University Of Lausanne, Lausanne, Switzerland.
Phone: 41-21-692-53-90
Fax: 41-21-692-5355
E-mail: bernard.thorens@ipharm.unil.ch
View the PDF of this article at: https://www.the-jci.org/press/16888.pdf
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