image: PBP2 is mislocalized by PC190723. Images obtained by fluorescence microscopy showing the localization of the protein PBP2, required for the synthesis of the cell wall of bacteria, fused to the green fluorescent protein GFP in untreated Staphylococcus aureus cells (A), cells treated with lower (B) and higher (C) concentrations of the FtsZ inhibitor PC190723. Arrows point to protein localized at the division site of bacterial cells. Scale bar: 1 um. This image relates to a paper that appeared in the March 21, 2012, issue of Science Translational Medicine, published by AAAS. The paper, by C.M. Tan at Merck Research Laboratories in Kenilworth N.J., and colleagues was titled, "Restoring Methicillin-Resistant Staphylococcus aureus Susceptibility to β-Lactam Antibiotics." view more
Credit: Image © <i>Science</i>/AAAS