image: Histopathology of a biopsied metastatic lesion [from patient 10031016 (left)] and a surgically resected primary pancreatic lesion [from patient 10061003 (right)]. Both patients achieved a PR. Patient 10031016 underwent tumor biopsy after completing four cycles of therapy; patient 10061003 underwent surgical resection of the primary tumor after 12 cycles of therapy. Arrows (left) indicate a macrophage-dominated inflammatory infiltrate within extensive tumor necrosis. Arrows (right) identify polymorphonuclear infiltrating cells without lymphocytes; arrowheads mark tumor cells. Scale bars, 50 mm. For more information, please see Figure 1 in the manuscript. This image relates to an article that appeared in the March 25, 2011, issue of Science, published by AAAS. The study, by Dr. Beatty, at University of Pennsylvania School of Medicine in Philadelphia, and colleagues was titled, "CD40 Agonists Alter Tumor Stroma and Show Efficacy Against Pancreatic Carcinoma in Mice and Humans." view more
Credit: [Image courtesy of <i>Science/</i>AAAS]