image: In unaffected wild-type brain, Notch receptor is expressed and active only in arteries. Arterial markers (such as EphrinB2, Dll4, Jag1, and Cx40) induced by Notch activity are also confined to the artery. The vein expresses a distinct set of markers, including genes upsteam (Coup-TFII) and downstream of Notch (EphB4). This image relates to a paper that appeared in the Jan. 18, 2012, issue of Science Translational Medicine, published by AAAS. The paper, by Dr. P.A. Murphy of the University of California, San Francisco in San Francisco, Calif., and colleagues, was titled, “Notch4 Normalization Reduces Blood Vessel Size in Arteriovenous Malformations.” view more
Credit: Image courtesy of <i>Science</i>/AAAS