image: Super-resolution fluorescence microscope image of a cluster of PIM1-treated Pseudomonas aeruginosa cells. Cells are 1-2 micrometers in length. Green is the bacterial cell membrane. Red is PIM1. Yellow is PIM1 in the membrane. view more
Credit: Image credit: Lin Ruan
对合成主链阳离子聚咪唑鎓分子充当广谱抗生素的有效性的一项研究发现，衍生化合物表现出了低毒性的有效的抗菌效应，而革兰氏阴性病原体绿脓杆菌无法进化出耐受聚咪唑鎓 的菌株，这提示这一类化合物可能是应对抗生素耐药菌的药物开发的候选。
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Journal
Proceedings of the National Academy of Sciences