image: ID93/GLA-SE vaccine confers long-term protection against Mtb in guinea pigs in a BCG prime/protein boost regimen. Guinea pigs received a single injection of either saline (one of three groups) or BCG (two groups). Four months later, BCG-primed animals received the ID93/GLA-SE vaccine or saline. Granulomas are shown in H&E-stained sections, and Masson’s trichrome (TC) stain was used to assess the amount of lung fibrosis in blue. Scale bar, 20 micrometers. See figure 5 in the manuscript for more information. This image relates to an article that appeared in the Oct. 13, 2010, issue of Science Translational Medicine, published by AAAS. The study, by Dr. S. Berthole of Infectious Disease Research Institute in Seattle, Wash., and colleagues, is titled, "A Defined Tuberculosis Vaccine Candidate Boosts BCG and Protects Against Multidrug-Resistant Mycobacterium tuberculosis." view more
Credit: Image courtesy of Science/AAAS