image: Damage-Induced Checkpoint Activation Regulation of the mammalian cell cycle is accomplished by multiple protein-protein interactions and phosphorylation events, which promote the progression from G1 to cell division in mitosis. DNA damage-inducing agents such as ionizing radiation or ultraviolet light disrupt the cell cycle by compromising the integrity of the DNA. This activates cell cycle checkpoints, which inhibit cell cycle progression until the damage is repaired. The events that take place during each phase of the cell cycle and the mechanisms by which these events can be inhibited by DNA damage-induced checkpoint activation are highlighted. This image relates to an article that appeared in the Feb. 19, 2010, issue of Science, published by AAAS. The article was titled, "2009 International Science and Engineering Visualization Challenge." view more
Credit: Image courtesy of Erin Olson, Daphne Orlando, and Tim Manning, R&D Systems, Inc.