image: Immunohistochemical staining revealed that brain-derived neurotrophic factor in brain tissue surrounding the hematoma further increased after treatment with 20 g/kg Poxue Huayu and Tianjing Busui Decoction, and the effects were identical to that of Xingnao Jianshen Capsule. view more
Credit: <i>Neural Regeneration Research</i>
Dr. Jixiang Ren and team from the Affiliated Hospital to Changchun University of Chinese Medicine proposed a therapeutic principle for Poxue Huayu and Tianjing Busui (i.e., breaking blood stasis, replenishing essence). The researchers established cerebral hemorrhage rat models which were intragastrically administered 5, 10, 20 g/kg Poxue Huayu and Tianjing Busui Decoction, supplemented with Hirudo, raw rhubarb, raw Pollen Typhae, gadfly, Fructrs Trichosanthis, Radix Notoginseng, Rhizoma Acori Talarinowii, and glue of tortoise plastron, once a day, for 14 consecutive days. Their findings, which were published in the Neural Regeneration Research (Vol. 8, No. 22, 2013), demonstrated that brain water content significantly reduced in rats with cerebral hemorrhage, and intracerebral hematoma volume markedly reduced after treatment. Brain-derived neurotrophic factor, tyrosine kinase B and vascular endothelial growth factor expression noticeably increased around the surrounding hematoma. Moreover, neurologic impairment obviously reduced. Poxue Huayu and Tianjing Busui Decoction can markedly elevate the expression of brain-derived neurotrophic factor, tyrosine kinase B and vascular endothelial growth factor in the brain, thereby providing a new scientific therapeutic method for protecting neurons after cerebral hemorrhage.
Article: " Poxue Huayu and Tianjing Busui Decoction for cerebral hemorrhage: upregulation of neurotrophic factor expression," by Jixiang Ren1, Xiangyu Zhou2, Jian Wang1, Jianjun Zhao1, Pengguo Zhang3 (1 Department of Encephalopathy, the Affiliated Hospital to Changchun University of Chinese Medicine, Changchun 130021, Jilin Province, China; 2 Grade 2010 Clinical Medicine Major, School of Clinical Medicine, Yanbian University, Yanji 133002, Jilin Province, China; 3 Department of Imaging, School of Second Clinical Medicine, Jilin University, Changchun 130041, Jilin Province, China)
Ren JX, Zhou XY, Wang J, Zhao JJ, Zhang PG. Poxue Huayu and Tianjing Busui Decoction for cerebral hemorrhage: upregulation of neurotrophic factor expression. Neural Regen Res. 2013;8(22):2039-2049.
Contact: Meng Zhao
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Neural Regeneration Research