image: Losartan improves muscle remodeling and in vivo function in sarcopenic mice. Histological analyses of the tibialis anterior (TA) muscle after cardiotoxin (CT) injection of placebo-treated (left) and losartan-treated (right) 21-month-old C57BL/6 male mice. Hematoxylineosin (H&E) (A) shows evidence of early signs of regeneration indicated by open arrows and no phenotypic differences between the treatment groups. Developmental myosin immunofluorescence (B) confirms similar amounts of newly regenerating cells. H&E staining (C) at 19 days after CT reveals impaired regeneration in the placebo-treated animal evident by fibrosis (closed arrow). Scale bar, 200 mm. For more information, please see Figure 1 in the manuscript. This image relates to a paper that appeared in the May 11, 2011, issue of Science Translational Medicine, published by AAAS. The paper, by Dr. T.N. Burks of Johns Hopkins University School of Medicine in Baltimore, Md. and colleagues, was titled, "Losartan Restores Skeletal Muscle Remodeling and Protects Against Disuse Atrophy in Sarcopenia." view more
Credit: Image courtesy of Science/AAAS