image: A mitotic chromosome spread from a dividing human cancer cell. The sister chromatids in this cell are not properly cohered due to mutational inactivation of the STAG2 gene. The lack of sister chromatid cohesion will result in an abnormal division of the chromosomes leading to aneuploidy (an abnormal number of chromosomes) in the two daughter cells. For more information, please see Figure 3 in the manuscript. This image relates to an article that appeared in the Aug. 19, 2011, issue of Science, published by AAAS. The study, by Dr. D.A. Solomon of the Georgetown University School of Medicine in Washington, D.C., and colleagues was titled, "Mutational Inactivation of STAG2 Causes Aneuploidy in Human Cancer." view more
Credit: Image courtesy of Science/AAAS