Smoking before menopause, especially prior to giving birth, may be associated with a modest increase in the risk of developing breast cancer, according to a report in the January 24 issue of Archives of Internal Medicine, one of the JAMA/Archives journals.
"Breast cancer is the most common cancer to affect women worldwide," according to background information in the article. "Tobacco smoke contains potential human breast carcinogens, including polycyclic aromatic hydrocarbons, aromatic amines and N-nitrosamines."
Using data collected from the Nurses' Health Study, Fei Xue, M.D., Sc.D., of Brigham and Woman's Hospital and Harvard Medical School, Boston, and colleagues examined the records of 111,140 women from 1976 to 2006 for active smoking and 36,017 women from 1982 to 2006 for passive (secondhand) smoking.
A total of 8,772 breast cancer cases developed during follow-up. The development of breast cancer was associated with a higher quantity of current and past smoking, smoking for a longer period of time, younger age at smoking initiation and more pack-years (product of the number of packs per day and the number of years that quantity was smoked) of smoking.
"Smoking before menopause was positively associated with breast cancer risk, and there were hints from our results that smoking after menopause might be associated with a slightly decreased breast cancer risk," the authors write. "This difference suggests an antiestrogenic effect of smoking among postmenopausal women that may further reduce their already low endogenous estrogen levels."
Conversely, never smoking and passive smoking in childhood or adulthood were not associated with an increase in breast cancer risk. Exposure to parents who smoked while living in the same house, passive smoking while at work or at home and the number of years living with someone who smoked were not related to increased risk of breast cancer after adjusting for other possible factors.
"In the present study, we created an index of active smoking that integrates quantity, age at which one started smoking and duration of smoking," the authors conclude. "The results suggested that, although an elevated risk for light smokers and moderate smokers was not apparent, heavy smokers who started smoking early in life, smoked for a long duration and smoked a high quantity were at the highest risk of breast cancer, supporting an independent and additive effect from various smoking measures on breast carcinogenesis."
(Arch Intern Med. 2011;171[2]:125-133. Available pre-embargo to the media at www.jamamedia.org.)
Editor's Note: The Nurses' Health Study is supported by a grant from the National Cancer Institute, National Institutes of Health. Please see the article for additional information, including other authors, author contributions and affiliations, financial disclosures, funding and support, etc.
To contact Fei Xue M.D., Sc.D, call Holly Brown-Ayers at 617-534-1603 or e-mail hbrown-ayers@partners.org.
For more information, contact JAMA/Archives Media Relations at 312/464-JAMA (5262) or e-mail mediarelations@jama-archives.org.
Journal
Archives of Internal Medicine