image: T cells develop from multipotent precursor cells to arm the human adaptive immune system against foreign invaders. The strength of T cell receptor expression has long been believed to determine the developmental path of these cells. Sherwood et al. utilizes a high-throughput sequencing technology to refute this standard model. This image relates to a paper that appeared in the July 6, 2011, issue of Science Translational Medicine, published by AAAS. The paper, by Dr. A.M. Sherwood of Adaptive TCR in Seattle, Wash., and colleagues, was titled, "Deep Sequencing of the Human TCRγ and TCRβ Repertoires Suggests that TCRβ Rearranges After αβ and γδ T Cell Commitment.” view more
Credit: Image © Science/AAAS