video: Fibrin embolus extravasated out from a large pulmonary microvessel. Confocal imaging of a 50 μm sized fibrin clot (red, yellow arrow) that had extravasated out from the adjacent large pulmonary microvessel (yellow arrowhead) into the alveolar space 9 days after embolization. Small fragments of the clot (red) that remained to be cleared are also noted in the vessel. The extravasated clot was surrounded by isolectin B4 (IB4)-labeled alveolar macrophages (green, white arrows). Cells within an adjacent bronchial branch are indicated with a cyan arrow [these cells are labeled by IB4 (green)]. Scale bar, 100 μm. This video relates to a paper that appeared in the March 5, 2014, issue of Science Translational Medicine, published by AAAS. The paper, by Dr. J. Grutzendler at Yale University School of Medicine in New Haven, Conn., and colleagues was titled, "Angiophagy Prevents Early Embolus Washout But Recanalizes Microvessels Through Embolus Extravasation." view more
Credit: Video courtesy of <i>Science Translational Medicine</i>/AAAS