image: STIM-ulating Orai1 and un-STIM-ulating Cav1.2. This diagram illustrates how STIM1 in the ER membrane activates Orai1 (green subunits) and inhibits Cav1.2 (brown subunits) in the plasma membrane (PM). Please see the Perspective for the complete caption. This image relates to a Perspective that appeared in the October 1, 2010, issue of Science, published by AAAS. The Perspective, by Dr. Michael D. Cahalan of the University of California, Irvine in Irvine, Calif., was titled, "A Stimulating Look At Calcium Channels.” view more
Credit: Image: Science © 2010 AAAS