image: This image shows a combination of glial-restricted precursor-derived astrocytes induced by bone morphogenetic protein-4 transplantation and human recombinant decorin injection could effectively promote sensory and motor axonal regeneration within the contusive spinal cord of rats at 28 days after injury. view more
Credit: <i>Neural Regeneration Research</i>
Following spinal cord injury, astrocyte proliferation and scar formation are the main factors inhibiting the regeneration and growth of spinal cord axons, leading to motor and sensory function loss below the level of spinal cord injury. Cell transplantation, bioengineering technology, drugs and other methods can reduce voids of injured spinal cord and suppress glial scar formation, but clinical application results show these methods used alone have no obvious effects. Liang Wu and colleagues from Capital Medical University used rat models of T8 spinal cord contusion, which were subjected to combined transplantation of bone morphogenetic protein-4-induced glial-restricted precursor-derived astrocytes and human recombinant decorin transplantation. This combined transplantation promoted axonal regeneration and growth of injured motor and sensory neurons by inhibiting astrocyte proliferation and glial scar formation, with astrocytes forming a linear arrangement in the contused spinal cord, thus providing axonal regeneration channels. This combined transplantation provides a potential new therapy for experimental research and clinical transformation for the repair of spinal cord injury. These findings were published in the Neural Regeneration Research (Vol. 8, No. 24, 2013).
Article: " Combined transplantation of GDAsBMP and hr-decorin in spinal cord contusion repair," by Liang Wu1, 2, 3, Jianjun Li1, 2, Liang Chen1, 2, Hong Zhang1, Li Yuan1, 2, Stephen JA Davies4 (1 Rehabilitation Medicine, Capital Medical University, Beijing 100068, China; 2 Department of Neural Functional Reconstruction of Spine and Spinal Cord, China Rehabilitation Research Center, Beijing 100068, China; 3 Rehabilitation Center, Beijing Xiaotangshan Rehabilitation Hospital, Beijing 102211, China; 4 Department of Neurosurgery, University of Colorado Denver, 1250 14th Street Denver, Colorado 80217, USA)
Wu L, Li JJ, Chen L, Zhang H, Yuan L, Davies SJ. Combined transplantation of astrocytes and decorin in spinal cord contusion repair. Neural Regen Res. 2013;8(24):2236-2248.
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Journal
Neural Regeneration Research