image: The immune response generated by delivering lipid nanocapsules loaded with anti-cancer antigens (left) is compared to the same response generated by traditional soluble vaccines (right). Blue stain marks nuclei of cells in the tissue. Lung tissue sections immunized with the lipid nanocapsule vaccine show sustained retention of nanocapsule-loaded antigens (red) in the tissue near antigen-presenting cells (green). This retention is not discernible in the lung tissue immunized with the soluble vaccine. Scale bars 50 µm. This image relates to a paper that appeared in the September 25, 2013, issue of Science Translational Medicine, published by AAAS. The paper, by A.V. Li at the Massachusetts Institute of Technology in Cambridge, Mass., and colleagues was titled, "Generation of Effector Memory T Cell–Based Mucosal and Systemic Immunity with Pulmonary Nanoparticle Vaccination." view more
Credit: Adrienne V. Li, James J. Moon, Darrell J. Irvine