image: Immunolabelling of Minidysferlin in monocytes evidencing plasma membrane staining. Dysferlin is mainly expressed in skeletal muscle but also in blood mononuclear cells (monocytes). The latter represents an excellent cellular model, easier and less invasive to obtain than muscle biopsy samples. These pictures represent the fluorescent expression of natural minidysferlin at the plasma membrane in a patient with moderate disease. This image relates to an article that appeared in the Sept. 22, 2010, issue of Science Translational Medicine, published by AAAS. The study, by Dr. Martin Krahn of INSERM in Marseille, France, and colleagues, is titled, "A Naturally Occurring Human Minidysferlin Protein Repairs Sarcolemmal Lesions in a Mouse Model of Dysferlinopathy." view more
Credit: [Image courtesy of Nicolas Lévy—INSERM UMR_S 910—Marseille, France]