image: Structure of mature flaviviruses. Surface view of mature ZIKV showing the E proteins arranged in a herringbone pattern. The three E protomers within one icosahedral asymmetric unit are shown in blue, red and green. Three E dimers form a raft. view more
Credit: Image courtesy of Feng Long.
A study of Zika virus in murine models found that mice injected with a single dose of ZIKV-195, a neutralizing monoclonal antibody, 5 days after viral exposure were protected against the virus; the findings suggest that ZIKV-195 cross-links viral envelope proteins that are critical for viral and cellular membrane fusion, which in turn neutralizes Zika virus, according to the authors.
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Article #18-15432: "Structural basis of a potent human monoclonal antibody against Zika virus targeting a quaternary epitope," by Feng Long et al.
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Proceedings of the National Academy of Sciences