image: Between 4 and 6 months of age, full thickness cartilage lesions developed in mice lacking FoxO proteins. Rodents lacking FoxO1 developed severe cartilage lesions at 6 months, whereas those lacking FoxO3 and FoxO4 showed no histological cartilage abnormalities up to 6 months of age. view more
Credit: T. Matsuzaki <i>et al., Science Translational Medicine </i>(2018)