image: (A) Protein dynamics of individual living human cancer cells responding to an anti-cancer drug. Top panel: Protein fluorescence and individual cell boundaries in a series of consecutive frames are indicated by green spots surrounded by white silhouettes. Bottom panel: The dynamics of the protein DDX5 shows increased cell-to-cell variability beginning 12 hours after drug addition. This variability was found to be correlated with cell fate, survival or death. (B) The balance between degradation and dilution rates of 100 proteins. This image relates to Dr. Eran Eden's Essay, "Proteome dynamics and the fate of individual cancer cells in response to a drug." This image relates to an article that appeared in the Dec. 2, 2011, issue of Science, published by AAAS on the winner and runners-up of the GE & Science Prize for Young Life Scientists. view more
Credit: [Image © <i>Science</i>/AAAS]