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Why Does Inflammation Enhance Pain Relief from Opioids? (2 of 2)

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American Association for the Advancement of Science (AAAS)

Why Does Inflammation Enhance Pain Relief from Opioids? (2 of 2)

image: Activating the TRPV1 channel (red) with the inflammatory molecule capsaicin prevented the internalization of the mu opioid receptor (green) in human kidney cells treated with DAMGO, a synthetic opioid. This material relates to a paper that appeared in the April 2, 2019, issue of Science Signaling published by AAAS. The paper, by L. Basso at Alberta Children's Hospital Research Institute in Calgary, AB, Canada; and colleagues was titled, "TRPV1 promotes opioid analgesia during inflammation." view more 

Credit: L. Basso <i>et al., Science Signaling </i>(2019)


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