image: Coronary microvascular dysfunction in sunitinib-treated mice is associated with loss of pericytes. Representative scanning electron micrographs of the cardiac microvasculature from (top) control- or (bottom) sunitinib-treated mice after 14 days of treatment. Pseudocoloring is used (green for pericytes, red for microvessels) to aid in distinguishing pericytes from underlying microvessels. This image relates to a paper that appeared in the May 29, 2013, issue of Science Translational Medicine, published by AAAS. The paper, by Dr. V. Chintalgattu at Amgen, Inc. in South San Francisco, Calif., and colleagues was titled, "Coronary Microvascular Pericytes Are the Cellular Target of Sunitinib Malate–Induced Cardiotoxicity." view more
Credit: Image courtesy of <i>Science Translational Medicine</i>/AAAS