Acta Pharmaceutica Sinica B volume 15, Issue 3 publishes

https://www.sciencedirect.com/journal/acta-pharmaceutica-sinica-b/vol/15/issue/3

Acta Pharmaceutica Sinica B (APSB) was founded with the goal of creating a global high-level forum centred around drug discovery and pharmaceutical research/application. APSB was included by Chemical Abstracts in 2011, accepted by PubMed Central in 2015, indexed by Science Citation Index in 2017 and has evolved to become one of the most important international journals in the field of pharmaceutical sciences.

APSB is a monthly journal, in English, which publishes significant original research articles, rapid communications and high-quality reviews of recent advances in all areas of pharmaceutical sciences — including pharmacology, pharmaceutics, medicinal chemistry, natural products, pharmacognosy, pharmaceutical analysis and pharmacokinetics.

Articles of interest in this issue include:

 

A retrospective cohort study of the efficacy and safety of oral azvudine versus nirmatrelvir/ritonavir in elderly hospitalized COVID-19 patients aged over 60 years by Bo Yu, Haiyu Wang, Guangming Li and colleagues, (https://doi.org/10.1016/j.apsb.2024.12.032). This study used five analytical methods to show that azvudine has a therapeutic effect in elderly COVID-19 patients aged over 60 years.

 

Establishment of interpretable cytotoxicity prediction models using machine learning analysis of transcriptome features by You Wu, Ke Tang, Chunzheng Wang, Hao Song, Fanfan Zhou and Ying Guo, (https://doi.org/10.1016/j.apsb.2025.02.009). This study provides highly accurate models for 50% and 80% cell viability prediction and the key features which could facilitate the MOA study of substance with a narrow therapeutic index.

 

Parabacteroides distasonis promotes liver regeneration by increasing β-hydroxybutyric acid (BHB) production and BHB-driven STAT3 signals by Manlan Guo, Xiaowen Jiang, Hui Ouyang and colleagues, (https://doi.org/10.1016/j.apsb.2025.01.024). Parabacteroides distasonis promotes liver regeneration by increasing BHB production and BHB-driven STAT3 signals, which provides a relevant argument for using P. distasonis or BHB as a potential strategy for promoting hepatic regeneration after PHx or transplantation.

 

Other articles include:

 

Special Column: Nanomedicines for Tumor Microenvironment Modulation

Research articles

Intravenous delivery of STING agonists using acid-sensitive polycationic polymer-modified lipid nanoparticles for enhanced tumor immunotherapy

Ying He, Ke Zheng, Xifeng Qin, Siyu Wang, ... Zhiqing Pang

 

Bispecific killer engager for targeted depletion of PD-1 positive lymphocytes: A new avenue for autoimmune disease treatment

Lauren C. Naatz, Shuyun Dong, Brian Evavold, Xiangyang Ye, Mingnan Chen

 

Remodeling tumor immunosuppressive microenvironment through dual activation of immunogenic panoptosis and ferroptosis by H2S-amplified nanoformulation to enhance cancer immunotherapy

Yingli Luo, Maoyuan Linghu, Xianyu Luo, Dongdong Li, ... Yinchu Ma

 

Disrupting calcium homeostasis and glycometabolism in engineered lipid-based pharmaceuticals propel cancer immunogenic death

Qiuxia Peng, Xiaolong Li, Chao Fang, Chunyan Zhu, ... Kun Zhang

 

Review articles

The ubiquitin–proteasome system: A potential target for the MASLD

Yue Liu, Meijia Qian, Yonghao Li, Xin Dong, ... Qiaojun He

 

Comprehensive investigation of multiple targets in the development of newer drugs for the Alzheimer's disease

Patil Ashwini, Bodhankar Subhash, Muthal Amol, Dileep Kumar, ... Kulkarni Ravindra

 

Revolutionizing tuberculosis treatment: Breakthroughs, challenges, and hope on the horizon

Martin Kufa, Vladimir Finger, Ondrej Kovar, Ondrej Soukup, ... Jan Korabecny

 

 

 

 

 

Research articles

Targeting farnesoid X receptor as aging intervention therapy

Lijun Zhang, Jing Yu, Xiaoyan Gao, Yingxuan Yan, ... Shengjie Fan

 

Long-chain acylcarnitine deficiency promotes hepatocarcinogenesis

Kaifeng Wang, Zhixian Lan, Heqi Zhou, Rong Fan, ... Jian Sun

 

Nitazoxanide protects against heart failure with preserved ejection and metabolic syndrome induced by high-fat diet (HFD) plus L-NAME “two-hit” in mice

Jiahui Chen, Liping Zhang, Ting Xie, Xiao Zhang, ... Deli Dong

 

Effective therapeutic targeting of tumor lineage plasticity in neuroendocrine prostate cancer by BRD4 inhibitors

Xiong Zhang, Yatian Yang, Hongye Zou, Yang Yang, ... Hong-Wu Chen

 

A synthetic peptide, derived from neurotoxin GsMTx4, acts as a non-opioid analgesic to alleviate mechanical and neuropathic pain through the TRPV4 channel

ShaoXi Ke, Ping Dong, Yi Mei, JiaQi Wang, ... QiongYao Tang

 

Novel carbazole attenuates vascular remodeling through STAT3/CIAPIN1 signaling in vascular smooth muscle cells

Joo-Hui Han, Jong-Beom Heo, Hyung-Won Lee, Min-Ho Park, ... Chang-Seon Myung

 

Diabetes-associated sleep fragmentation impairs liver and heart function via SIRT1-dependent epigenetic modulation of NADPH oxidase 4

Yuanfang Guo, Jie Wang, Dongmei Zhang, Yufeng Tang, ... Junlian Gu

 

Ginsenoside CK targets PHD2 to prevent platelet adhesion and enhance blood circulation by modifying the three-dimensional arrangement of collagen

Chuanjing Cheng, Kaixin Liu, Jinling Zhang, Yanqi Han, ... Gang Bai

 

Dihydromyricetin mitigates abdominal aortic aneurysm via transcriptional and post-transcriptional regulation of heme oxygenase-1 in vascular smooth muscle cells

Weile Ye, Pinglian Yang, Mei Jin, Jiami Zou, ... Zhiping Liu

 

STK39 inhibits antiviral immune response by inhibiting DCAF1-mediated PP2A degradation

Chengfei Zhang, Ping Xu, Yongsheng Wang, Xin Chen, ... Hongping Xia

 

BRD4 regulates m⁶A of ESPL1 mRNA via interaction with ALKBH5 to modulate breast cancer progression

Haisheng Zhang, Linlin Lu, Cheng Yi, Tao Jiang, ... Hongsheng Wang

 

eIF3a function in immunity and protection against severe sepsis by regulating B cell quantity and function through m⁶A modification

Qianying Ouyang, Jiajia Cui, Yang Wang, Ke Liu, ... Jiye Yin

 

Parkin inhibits iron overload-induced cardiomyocyte ferroptosis by ubiquitinating ACSL4 and modulating PUFA-phospholipids metabolism

Dandan Xiao, Wenguang Chang, Xiang Ao, Lin Ye, ... Jianxun Wang

 

CDK5-triggered G6PD phosphorylation at threonine 91 facilitating redox homeostasis reveals a vulnerability in breast cancer

Yuncheng Bei, Sijie Wang, Rui Wang, Owais Ahmad, ... Pingping Shen

 

Optineurin restrains CCR7 degradation to guide type II collagen-stimulated dendritic cell migration in rheumatoid arthritis

Wenxiang Hong, Hongbo Ma, Zhaoxu Yang, Jiaying Wang, ... Qinjie Weng

 

USP25 ameliorates vascular remodeling by deubiquitinating FOXO3 and promoting autophagic degradation of FOXO3

Yanghao Chen, Bozhi Ye, Diyun Xu, Wante Lin, ... Guang Liang

 

Discovery of a potential hematologic malignancies therapy: Selective and potent HDAC7 PROTAC degrader targeting non-enzymatic function

Yuheng Jin, Xuxin Qi, Xiaoli Yu, Xirui Cheng, ... Xiaowu Dong

 

Discovery of a novel polymyxin adjuvant against multidrug-resistant gram-negative bacteria through oxidative stress modulation

Taotao Lu, Hongguang Han, Chaohui Wu, Qian Li, ... Baoli Li

 

Letter to the editor

Lycorine hydrochloride directly targets UBA1 to suppress cellular senescence

Jiaqing Yang, Junhao Xu, Ziheng Qiu, Zhiyong Mao, ... Guizhu Wu

 

Highlights

Monocytes in the brain–heart crosstalk control sleep under myocardial infarction

Meng Mao, Hailong Bing, Jianping Ye, Zhengyuan Xia, Qinjun Chu

 

Engineered bacteria assist CAR-cell immunotherapy

Tianyu Shao, Manman Xu, Jie Li, Xiao Zhao

 

Silencing excessive stress response of neurons — a new approach to treat neurodegeneration diseases

Chunyang Li, Hongkai Lian, Xiwen Ma, Jianping Ye

 

Commentaries

Liquid–liquid phase separation-assembled coacervate vesicles for biopharmaceutical delivery

Zao Ji, Jianbin Bi, Hong-Xu Liu, Heran Li

 

Evaluation of the efficacy and mechanisms of azvudine in elderly patients with malignant tumors complicated by COVID-19

Ranran Sun, Yihang Song, Zhe Li, Daming Wang, Zujiang Yu

Unlocking the potential of the gut microbiome in liver regeneration: Benefits and mechanistic insights

Wenchao Wei, Bernd Schnabl

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The Journal of the Institute of Materia Medica, the Chinese Academy of Medical Sciences and the Chinese Pharmaceutical Association.

For more information please visit https://www.journals.elsevier.com/acta-pharmaceutica-sinica-b/

Editorial Board: https://www.journals.elsevier.com/acta-pharmaceutica-sinica-b/editorial-board

 

APSB is available on ScienceDirect (https://www.sciencedirect.com/journal/acta-pharmaceutica-sinica-b).

 

Submissions to APSB may be made using Editorial Manager® (https://www.editorialmanager.com/apsb/default.aspx).

 

CiteScore: 22.4

Impact Factor: 14.8

JIF without self-citation: 13.9

 

ISSN 2211-3835

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