News Release

PCORI announces new research opportunities to address critical health challenges

Funding opportunities invite proposals for patient-centered CER for a range of conditions, including IDD, maternal health and dementia

Business Announcement

Patient-Centered Outcomes Research Institute

New Research Opportunities To Address Critical Health Challenges

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Every day, millions of people facing health challenges make decisions about their care without adequate information to understand the tradeoffs between available options. To help close these evidence gaps, the Patient-Centered Outcomes Research Institute (PCORI) funds patient-centered comparative clinical effectiveness research (CER) and related projects. 

PCORI is announcing new funding opportunities for patient-centered CER focused on a range of health concerns, including intellectual and developmental disabilities, violence and trauma, maternal health and dementia.  

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Credit: Patient-Centered Outcomes Research Institute (PCORI)

WASHINGTON, D.C. — Every day, millions of Americans facing health challenges make decisions about their care without adequate information to understand the tradeoffs between available options. To help close these evidence gaps, the Patient-Centered Outcomes Research Institute (PCORI) is announcing new funding opportunities for patient-centered comparative clinical effectiveness research (CER) and related projects focused on a range of health concerns, including intellectual and developmental disabilities (IDD), violence and trauma, maternal health and dementia.

Patient-centered CER compares two or more healthcare options to generate evidence about any differences in potential benefits or harms and gives patients and those who care for them information to make informed decisions that reflect their needs and preferences.

Among the four CER PCORI Funding Announcements (PFAs) opening today, two are focused on:

  • Intellectual and Developmental Disabilities: Proposals for patient-centered CER focused on improving care for people with IDD, particularly in areas such as oral and gastrointestinal health. 
  • Violence and Trauma: Proposals for patient-centered CER focused on clinical decisions for the care of individuals at risk for or who have been affected by violence and trauma, including both intentional and unintentional trauma as well as substance use linked to trauma.

Additionally, PCORI is inviting proposals for any patient-centered CER topic through the following PFAs: 

  • Broad Pragmatic Studies: Proposals for smaller-scale CER studies to compare care options in real-life practice conditions, including but not limited to questions related to maternal sleep health during pregnancy and postpartum or the mental and behavioral health challenges of individuals living with Alzheimer’s disease and related dementias as well as their care partners. 

In addition to funding patient-centered CER to generate evidence that empowers patients, caregivers and other healthcare decision makers with information to make informed choices that reflect their needs and preferences, PCORI supports initiatives to accelerate the implementation of PCORI-funded CER results into clinical practice. Through its Health Systems Implementation Initiative PFA, PCORI is inviting proposals for projects addressing hypertension, cancer treatment and mental health.

PCORI is also seeking proposals to improve methods development for conducting patient-centered CER and the science of engagement in patient-centered CER. 

Details about the most recent funding announcements are on PCORI’s website

About PCORI

The Patient-Centered Outcomes Research Institute (PCORI) is a nonprofit organization authorized by Congress to fund patient-centered comparative clinical effectiveness research (CER). CER compares two or more healthcare options, generating evidence about any differences in potential benefits or harms to empower patients, caregivers and other healthcare decision makers with information to make informed choices that reflect their needs and preferences. PCORI emphasizes the engagement of patients, caregivers and the broader healthcare community in all aspects of PCORI-funded research and research-related activities, including the dissemination and uptake of research findings.    


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