Repeated esophagogastroduodenoscopy and colonoscopy in the diagnosis of gastrointestinal bleeding

Gastrointestinal (GI) bleeding is a common and potentially life-threatening condition that requires prompt and accurate diagnosis. Esophagogastroduodenoscopy (EGD) and colonoscopy are the primary diagnostic modalities, but initial examinations may sometimes fail to identify the bleeding source. In such cases, repeated endoscopic evaluations can improve detection rates. This review explores the role of repeat EGD and colonoscopy in diagnosing GI bleeding, highlighting the conditions under which they are most beneficial and the challenges associated with their use.

Incidence and Causes of Gastrointestinal Bleeding

GI bleeding is classified into upper, middle, and lower GI bleeding based on the site of hemorrhage. Acute upper GI bleeding has an incidence of 84–160 cases per 100,000 individuals annually, with a 10% mortality rate. Peptic ulcers, variceal bleeding, and mucosal erosions are among the most common causes. Lower GI bleeding, with an incidence of 20–33 cases per 100,000 individuals, is frequently caused by diverticular disease, hemorrhoids, malignancies, and colitis. The diagnostic accuracy of EGD for upper GI bleeding is approximately 90–95%, whereas colonoscopy for lower GI bleeding has a diagnostic rate of 48–90%.

Role of Repeated EGD and Colonoscopy

Certain conditions, such as Dieulafoy’s disease, intermittent bleeding, and limited visualization during initial endoscopy, may necessitate repeated examinations. Repeated EGD has been shown to enhance lesion detection, particularly in cases where the initial examination is inconclusive due to active bleeding or poor visualization. Similarly, repeated colonoscopy is valuable for detecting colonic diverticular bleeding and assessing recurrent hemorrhages.

Indications for Repeat Endoscopy

Repeated EGD and colonoscopy should be considered in the following scenarios:

1. Poor Visualization During Initial Endoscopy - Blood clots, food residue, or inadequate bowel preparation can obscure lesions.
2. Incomplete Initial Examination - If the first procedure does not achieve full visualization of the GI tract.
3. Recurrent or Persistent Bleeding - Clinical evidence of ongoing hemorrhage may indicate a missed lesion.
4. Additional Imaging Suggests a Bleeding Source Within Endoscopic Reach - Findings from capsule endoscopy or CT angiography can guide repeat procedures.

Optimizing the Utility of Repeated Endoscopy

To minimize the need for repeat procedures, proper bowel preparation, experienced endoscopists, and advanced imaging modalities should be employed. Scheduling endoscopic examinations at appropriate times, particularly within 24 hours for high-risk patients, enhances diagnostic yield. Emerging technologies, such as water-jet-assisted colonoscopy and cap-assisted endoscopy, improve visualization and lesion detection rates.

Conclusions

Repeated EGD and colonoscopy play a critical role in diagnosing GI bleeding when initial examinations fail to identify the bleeding source. While routine repeat procedures are not always necessary, careful patient selection based on clinical factors can enhance diagnostic accuracy and improve patient outcomes. Further research is needed to establish standardized guidelines for repeat endoscopy in GI bleeding management.

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https://www.xiahepublishing.com/2994-8754/JTG-2024-00024

The study was recently published in the Journal of Translational Gastroenterology.

Journal of Translational Gastroenterology (JTG) dedicates to improving clinical diagnosis and treatment, advancing understanding of the molecular mechanisms, and promoting translation from bench to bedside of gastrointestinal, hepatobiliary, and pancreatic diseases. The aim of JTG is to provide a forum for the exchange of ideas and concepts on basic, translational, and clinical aspects of gastroenterology, and promote cross-disciplinary research and collaboration.

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