image: Identification of ferroptosis-related lncRNA. A Differential analysis of ferroptosis genes in AML. B Differential analysis of lncRNA in AML. C Correlation analysis between the differentially expressed ferroptosis genes and differentially expressed lncRNAs. Blue represents differentially expressed ferroptosis genes, red represents differentially expressed lncRNAs
Credit: Shuhan Liu, Yingli Chen, Qianzhong Li, Zhiyu Fan, Menglan Li, Pengyu Du
Key Findings:
- Researchers identified ten ferroptosis-related lncRNAs associated with AML prognosis.
- These lncRNAs were used to construct a prognostic model, effectively predicting patient survival.
- High-risk patients, identified by the model, exhibited higher mutation rates and immune infiltration compared to low-risk patients.
- The study suggests that the model could be useful for personalized treatment and predicting response to immunotherapy.
Implications:
This research provides valuable insights into the complex interplay between ferroptosis, lncRNAs, and the immune microenvironment in AML. The identified prognostic model holds promise for improving diagnosis, prognosis, and treatment strategies for AML patients.
The work entitled “A prognostic model for acute myeloid leukemia based on ferroptosis-related lncRNA and immune infiltration analysis” was published on Biophysics Reports (published on December, 2024).
Journal
Biophysics Reports
Method of Research
Experimental study
Subject of Research
Cells
Article Title
A prognostic model for acute myeloid leukemia based on ferroptosis-related lncRNA and immune infiltration analysis
Article Publication Date
1-Dec-2024