Meiotic maturation resulted by microplastics exposure can be attributed to HDAC3 insufficiency

Microplastics (MPs) are considered as one of the main causes of male and female infertility. However, the reproductive toxicity and its related mechanisms are currently understood primarily through animal models with acute exposure.

Qi Zhao et al. demonstrate that low-dose exposure to polystyrene microplastics (PSMPs) leads to severely abnormal reproduction in females, manifested by oocyte meiotic maturation defect.

Mechanistically, PSMPs exposure induce the overactivation of cell metabolism pathways, insufficient HDACs, and H4K16 hyperacetylation in oocytes both in vivo and in vitro. When an HDAC3 inhibitor is added, the oocyte maturation defect, overactivation of cell metabolism pathways, and H4K16 hyperacetylation are recapitulated. Conversely, the overexpression of HDAC3 can rescue the defects in meiotic maturation induced by PSMPs, suggesting a direct link between the maturation defects caused by PSMPs and HDAC3 insufficiency.

The study propose a potential treatment to address the meiotic maturation defect of oocytes in women highly exposed to MPs by activating or supplying HDAC3.

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