Biological clock plays critical role in driving teens’ late-day eating habits

PROVIDENCE, R.I. [Brown University] — The causes of obesity are complex and influenced by many factors. While research has highlighted connections between sleep, eating patterns and weight gain, scientists remain uncertain of the role of the circadian system — the biological clock — in shaping eating patterns. 

 But a new study from researchers at the Warren Alpert Medical School of Brown University and Mass General Brigham reveals a distinct relationship between circadian rhythms, weight and eating habits in adolescents, a vulnerable age group whose eating patterns influence their lifelong health. The study found that adolescents whose weight was classified as “overweight” or “obese” consumed more calories later in the day compared to participants with healthy weights.

The results demonstrate that circadian rhythms play an important role in explaining later caloric intake in individuals at risk for obesity, said lead investigator Mary Carskadon, a professor of psychiatry and human behavior at Brown’s medical school. 

“The critical nature of adolescent development to set the stage for a lifetime of health highlights the need to understand the roles played by sleep/wake and circadian timing processes for eating behavior,” said Carskadon, who also directs the Bradley Hospital Sleep Research Laboratory. “The knowledge gained here opens a door to potential interventions that can enhance teen health moving forward.”

The results were published in the Proceedings of the National Academy of Sciences.

Isolating circadian influences 

The circadian system is composed of trillions of “clocks” present in virtually all organs, tissues and cells, which prepares biology and behavior to adapt to the changing demands across the day/night cycle. The influence of the circadian system is known to differ between people due to a combination of genetic, behavioral and environmental factors.  

Previous studies have analyzed sleeping and eating behavior using measures of self-reported hunger and other variables, said study author David Barker, an associate professor of psychiatry and human behavior (research) at Brown. Some factors that set this study apart, Barker said, were the meticulous measuring of food before and after meals and the fact that environmental and behavioral influences were controlled for while the participants remained in the lab.

Fifty-one volunteers between the ages of 12 and 18 participated in the study, which was conducted at the Bradley Hospital Sleep Research Laboratory. Participants were divided into three groups based on body mass index. They were placed on 28-hour sleep and wake cycles — slightly longer than a typical 24-hour day — and stayed in a controlled dim-light setting while awake and in complete darkness during sleep.

Participants remained in the same space throughout the study, which lasted for 11 days and 10 nights. To control for outside influences on circadian rhythm, researchers removed all external time cues from the lab’s environment, including clocks and access to natural light. 

Participants received six opportunities to eat at fixed times across the wake episode, with a standardized menu and could consume as much food during the meal as they wanted. Researchers tracked the food that was eaten as well as caloric intake. During the day, they were monitored by student research apprentices from Brown University and other institutions, who offered opportunities to join in a variety of activities including making crafts, watching movies (with screen lights dimmed) and playing social games. 

The results showed that changes in the circadian system throughout the day and night significantly influenced food consumption. In all three groups, food intake peaked in the late afternoon and early evening and was lowest in the morning, even after accounting for behavioral and environmental factors, demonstrating that the body’s biological clock directly impacts how much people eat at different times of the day.

Adolescents in the obesity and overweight groups consumed significantly more calories in the circadian evening compared to those in the healthy weight group. Researchers found no significant differences in total sleep time between or within the groups across sleep cycles.

According to study author Frank Scheer, director of the Medical Chronobiology Program at Brigham and Women’s Hospital, it was already well known that the circadian system affects hunger and metabolism. What remained unclear, he said, was whether the circadian system — when isolated from influences of environmental and behavioral cycles, including light, sleep and activity cycles — directly influences food consumption. 

“This study is the first to demonstrate that food intake itself is regulated by our internal body clock,” Scheer said.

Body clocks, food intake and weight

Future studies are needed to determine whether affecting circadian control of food intake contributes to weight changes, if weight changes impact the circadian control of food intake, or a combination of the two. 

Carskadon said that the findings like those from the study could inform clinicians counseling adolescents on ways to manage their weight. 

“For example, the influence of circadian timing could be influenced by excluding light late in the day and enhancing bright light in the morning, especially while exercising,” Carskadon said. “That might help pull the rhythms to a better place — and also create healthy habits.”

With future research, the team aims to gain a deeper understanding of the interactions between the circadian system, diet and metabolism, as well as the mechanisms underlying these relationships, and the implications for developing timed dietary interventions to improve health. 

The research was supported by the National Institute of Diabetes and Digestive and Kidney Diseases (R01 DK101046), the National Heart, Lung, and Blood Institute (R01HL153969), the National Institutes of Health (R01-HL140574, R01-HL153969, R01-HL167746, R01-HL164454) and the COBRE Center for Sleep and Circadian Rhythms in Child and Adolescent Mental Health funded by the National Institute of General Medical Sciences (P20GM139743).