Relationship between SOCS1 levels and inhibition of GM-CSF signaling

New Rochelle, NY, January 14, 2024—A new study showed that SOCS1 regulation of GM-CSF signaling is dose-dependent. The study, which involved generating a novel mouse strain expressing a Halo-tag-SOCS1 fusion protein under control of the endogenous Socs1 promoter, is published in the peer-reviewed Journal of Interferon & Cytokine Research (JICR). Click here to read the article now.

Suppressor of Cytokine Signaling (SOCS) 1 is a key negative regulator of interferon (IFN), interleukin (IL)-12, and IL-2 family cytokine signaling.

“While the mechanisms that govern selective regulation by SOCS1 remain an enigma, one obvious possibility is that inhibition of signaling depends on exceeding a certain threshold in SOCS1 expression,” stated Professor Sandra Nicholson and Dr. Karen Doggett, from The Walter and Eliza Hall Institute, and coauthors. “Here we have characterized a new SOCS1 reporter mouse strain that expresses a Halo-tagged SOCS1 fusion protein under control of the endogenous Socs1 promoter elements. Cells from these mice were utilized to track SOCS1 expression and investigate the relationship between SOCS1 levels and inhibition of signaling.”

The investigators concluded that SOCS1 needs to exceed a threshold level to inhibit both IFN-gamma and GM-CSF signaling. Furthermore, “the ability of SOCS1 to cross-regulate GM-CSF signaling is directly related to the level of SOCS1 expression.”

“The findings described in this new report underscore the critical role of SOCS1 as a negative regulator of signal transduction mediated by multiple cytokines, including GM-CSF, says Journal of Interferon & Cytokine Research Executive Editor Raymond Donnelly, PhD.

About the Journal
Journal of Interferon & Cytokine Research (JICR) is an authoritative peer-reviewed journal published monthly online with open access options and in print that covers all aspects of interferons and cytokines from basic science to clinical applications. Journal of Interferon & Cytokine Research is an official journal of the International Cytokine & Interferon Society. Complete tables of content and a sample issue may be viewed on the JICR website.

About the Publisher
Mary Ann Liebert, Inc. is a global media company dedicated to creating, curating, and delivering impactful peer-reviewed research and authoritative content services to advance the fields of biotechnology and the life sciences, specialized clinical medicine, and public health and policy. For complete information, please visit the Mary Ann Liebert, Inc. website.