Special issue: Osteogenesis imperfecta from bench to bedside and from cradle to grave

In this topical issue of Calcified Tissue International, issue editors Lars Folkestad and Stuart H. Ralston present a collection of 14 critical reviews and original research articles that reflect the current state-of-the-art understanding of osteogenesis imperfecta (OI). The contributions cover essential aspects of OI, including its nosology, genetics, clinical presentation, and treatment strategies for both children and adults, as well as translational studies on bone mineralization in OI, and preclinical research utilizing animal models.

The Editors note: “The diverse and innovative topics that are highlighted in this special issue show the significant progress made in evaluating, managing, and developing therapeutic interventions for OI. We sincerely thank the authors for contributing their exceptional reviews and new research. It is our hope that these contributions will assist future research to bridge the gap between mechanistic insights and personalized care, with the aim of improving follow-up and treatment approaches for individuals with OI.”

We invite you to read and share the new articles and invited reviews:

• Editorial: Osteogenesis Imperfecta from Bench to Bedside and from Cradle to Grave  https://rdcu.be/d1SXG
  Folkestad, L., Ralston, S.H. (2024)
• A dyadic nosology for osteogenesis imperfecta and bone fragility syndromes 2024
  Sillence, D.O. (2024)
• Update on the genetics of osteogenesis imperfecta
  Jovanovic, M., Marini, J.C. (2024)
• Bone quality and mineralization and effects of treatment in osteogenesis imperfecta https://rdcu.be/d1SXM
  Misof, B.M., Fratzl-Zelman, N. (2024)
• Medical management for fracture prevention in children with osteogenesis imperfecta
  Arundel, P., Bishop, N. (2024)
• Current and developing pharmacologic agents for improving skeletal health in adults with osteogenesis imperfecta 
  https://rdcu.be/d1SXR
  Liu, W., Nicol, L., Orwoll, E. (2024)
• Orthopedic surgery in osteogenesis imperfecta in adults  https://rdcu.be/d1SXU
  Bizot, P. (2024)
• Osteogenesis imperfecta and the teeth, eyes, and ears-a study of non-skeletal phenotypes in adults
  Hald, J.D., Folkestad, L., Swan, C.Z., et al. (2018)
• Cardiovascular disease in patients with osteogenesis imperfecta - a nationwide, register-based cohort study 
  Folkestad, L., Hald, J.D., Gram, J., et al.  (2016)
• Skeletal and non-skeletal phenotypes in children with osteogenesis imperfecta  https://rdcu.be/d1SXY
  Marulanda, J., Retrouvey, JM., Rauch, F. (2024) 
• Osteogenesis imperfecta: skeletal and non-skeletal challenges in adulthood https://rdcu.be/d1SX2
  Hald, J.D., Langdahl, B., Folkestad, L. et al. (2024)
• Extra-skeletal manifestations in osteogenesis imperfecta mouse models
  Crawford, T.K., Lafaver, B.N., Phillips, C.L. (2024)
• Zebrafish models for skeletal and extraskeletal osteogenesis imperfecta features: unveiling pathophysiology and paving the way for drug discovery 
  Masiero, C., Aresi, C., Forlino, A. et al. (2024)
• Optimising health-related quality of life in children with osteogenesis imperfecta https://rdcu.be/d1SX4
  Hill, C.L., Ford, D. & Baker, J. (2024)
• Adapting to adulthood: a review of transition strategies for osteogenesis imperfecta 
  Celli, L., Garrelfs, M.R., Sakkers, R.J.B. et al. (2024)

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About Calcified Tissue International & Musculoskeletal Research
Calcified Tissue International & Musculoskeletal Research is a peer-reviewed journal that publishes original preclinical, translational and clinical research, and reviews concerning the structure and function of bone, and other musculoskeletal tissues in living organisms, as well as clinical studies of musculoskeletal disease. It includes studies of cell biology, molecular biology, intracellular signalling, and physiology, as well as research into the hormones, cytokines, and other mediators that influence the musculoskeletal system. The journal also publishes clinical studies of relevance to bone disease, mineral metabolism, muscle function, and musculoskeletal interactions. https://www.springer.com/journal/223  
Editors in Chief: Stuart H. Ralston and René Rizzoli; Musculoskeletal Research Section Editor: Roger Fielding.

About IOF
The International Osteoporosis Foundation (IOF) is the world's largest nongovernmental organization dedicated to the prevention, diagnosis and treatment of osteoporosis and related musculoskeletal diseases. IOF members, including committees of scientific researchers as well as more than 335 patient, medical and research organizations, work together to make fracture prevention and healthy mobility a worldwide heath care priority. https://www.osteoporosis.foundation   @iofbonehealth