image: The lysosome is a critical site for maintaining cellular catabolic function, ionic balance, nutrition sensing, metabolic balance and immunity balance. DC, dendritic cell.
Credit: By Meihua Hao, Sara C Sebag, Qingwen Qian, Ling Yang.
A new study published in [Journal] highlights the critical role of lysosomes, cellular organelles responsible for waste disposal and recycling, in the development and progression of diabetes. Researchers from [Institution] have uncovered the complex interplay between lysosomal function and the pathogenesis of various diabetes types, including type 1, type 2, gestational diabetes, and cystic fibrosis-related diabetes.
The study, titled “Lysosomal Stress in Pancreatic Endocrine Tissue in the Context of Diabetes Mellitus,” delves into the intricate mechanisms by which lysosomal dysfunction can lead to impaired insulin production, secretion, and glucose regulation. The researchers found that lysosomal stress, characterized by changes in pH, size, membrane permeability, and other factors, can disrupt the normal functioning of pancreatic beta cells, alpha cells, and immune cells.
The study found that lysosomal dysfunction can negatively impact various pancreatic cell types. In beta cells, it can lead to impaired insulin production and secretion. Alpha cells may experience lysosomal stress, contributing to excessive glucagon production, which can raise blood sugar levels. Immune cells can also be affected, with lysosomal dysfunction potentially causing inflammation and the destruction of beta cells in type 1 diabetes. Additionally, lysosomal stress in exocrine pancreatic cells can lead to pancreatitis, a condition that can also contribute to diabetes.
The study also explored the role of lysosomal dysfunction in various diseases, particularly diabetes. The researchers found that lysosomal stress, which occurs when lysosomes are unable to function properly, is associated with the development of diabetes.
These findings suggest that targeting lysosomal function could potentially lead to new therapeutic strategies for diabetes. By understanding the role of lysosomes in these diseases, researchers may be able to develop drugs that can restore normal lysosomal function and improve glycemic control.
See the article:
Hao M, Sebag SC, Qian Q, et al. Lysosomal physiology and pancreatic lysosomal stress in diabetes mellitus. eGastroenterology 2024;2:e100096. doi:10.1136/egastro-2024-100096
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Journal
eGastroenterology
Article Title
Lysosomal physiology and pancreatic lysosomal stress in diabetes mellitus