Air pollution exposure may be associated with eczema

People living in areas with higher levels of air pollution are more likely to have eczema, according to a new study published November 13, 2024 in the open-access journal PLOS ONE by Dr. Jeffrey Cohen of Yale School of Medicine, USA.

The prevalence of eczema has increased globally with industrialization, suggesting a possible contribution from environmental factors. In the new study, researchers used data from the U.S. National Institutes of Health All of Us Research Program, covering hundreds of thousands of U.S. adults. The current study included 286,862 people for whom there was available demographic, zip code and electronic health record data.

Overall, 12,695 participants (4.4%) were diagnosed with eczema. After controlling for demographics and smoking status, people with eczema were more likely to live in zip codes with high levels of fine particulate matter, or PM_2.5, in the air. For every increase of 10 µm/m³ in average PM_2.5 air pollution in their zip code, people were more than twice as likely to have eczema.

The authors conclude that increased air pollution, as measured by PM_2.5, may influence the risk of developing eczema, likely through its effects on the immune system.

The authors add: “Showing that individuals in the United States who are exposed to particulate matter are more likely to have eczema deepens our understanding of the important health implications of ambient air pollution.”

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In your coverage please use this URL to provide access to the freely available article in PLOS ONE: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0310498

Citation: Chen GF, Hwang E, Leonard CE, Cohen JM (2024) Association between fine particulate matter and eczema: A cross-sectional study of the All of Us Research Program and the Center for Air, Climate, and Energy Solutions. PLoS ONE 19(11): e0310498. https://doi.org/10.1371/journal.pone.0310498

Author Countries: U.S.

Funding: This study was partly funded by the National Institute on Aging (Grant No. 2 R01 AG060975) awarded to CEL. The funder also provided support in the form of salary for author CEL but did not have any additional role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript.