Anti-Inflammatory polyketides from Santalum album derived endophytic fungus Hypomontagnella sp. TX-09

Professor Chong Yan's team from Guangdong Medical University and Associate Professor Chen Senhua's team from Sun Yat-sen University have discovered: Chemical investigation of EtOAc extracts of the strain Hypomontagnella sp. TX-09 led to the purification of 13 polyketides (1–13), including four new lactones (1, 4–6) (Figure 1). The eight known polyketides were identified as nodulisporacid (2) (Huang et al. 2023), nodulisporacid A methyl ester (3) (Huang et al. 2023), isosporothric acid or colisiderin A (7) (Surup et al. 2014; Hu et al. 2015), xylariacinic B (8) (Yuan et al. 2021), xylariacinic C (9) (Yuan et al. 2021), xylariacinic A (10) (Yuan et al. 2021), dihydrosporothriolide (11) (Surup et al. 2014), p-hydroxybenzaldehyde (12) (Gao et al. 2023), and 7-carboxy-4-hydroxy-6-methoxy-5-methylphthalide (13) (Chen et al. 2021), respectively.

To summarize, we have discovered four previously unidentified lactones (1, 4−6) and nine known biogenetic derivatives (2−3 and 7−13) from the endophytic fungus Hypomontagnella sp. TX-09 derived from Santalum album. The stereochemistry of new compounds was elucidated in combination with ECD calculations, X-ray diffraction, and modified Mosher’s method. Anti-inflammatory pharmacological studies revealed that 1 and 2 have a strong anti-inflammatory effect against LPS-induced inflammation.

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Anti-inflammatory polyketides from Santalum album derived endophytic fungus Hypomontagnella sp. TX-09