image: TWP leachate disrupts intestinal homeostasis through TLR4/MyD88/NF-ĸBsignaling pathway, thereby inducing liver inflammation
Credit: Hangzhou Normal University
In a study published in Environmental Chemistry and Ecotoxicology, researchers from Hangzhou Normal University uncovered the adverse health effects of tire-wear particles (TWPs) on aquatic organisms. The study, led by Zhiquan Liu, focused on the hepatotoxicity of TWP leachates, revealing significant impacts on the gut-liver axis and oxidative stress levels in test organisms.
“TWPs, primarily produced through tire-road friction, are released into the environment in vast quantities,” says Liu. “Each year, approximately 6.1 million tons of TWPs are estimated to enter aquatic ecosystems, posing a significant threat to biodiversity.”
This prompted the researchers to investigate the effects of TWP leachates on black-spotted frogs (Pelophylax nigromaculatus), a highly susceptible amphibian species.
“We found that TWP leachates induced hepatic oxidative stress, inflammation and histopathology changes in the frogs. Specifically, increased levels of reactive oxygen species (ROS) and activation of signaling pathways closely related to immunity were observed,” shares Liu.
These changes were accompanied by disruptions in the gut microbiota, with a notable increase in Proteobacteria, a major source of gut-derived endotoxic lipopolysaccharide (LPS). Such disruptions in the gut-liver axis and oxidative stress levels can lead to long-term health issues for affected organisms.
The team also found that zinc, a trace metal commonly found in TWP leachates, accumulated in the intestine, liver and kidney of the test frogs, further confirming the absorption and bioaccumulation of TWP leachates by aquatic organisms.
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Contact the author: Zhiquan Liu liuzhiquan1024@163.com
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Journal
Environmental Chemistry and Ecotoxicology
Method of Research
Experimental study
Subject of Research
Animals
Article Title
Tire-wear particle leachate at environmentally relevant concentrations exert a hepatotoxic impact on the black-spotted frog by disrupting the gut–liver axis
COI Statement
The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.