About The Study: Among individuals with ulcerative colitis, the allele HLA-DRB1*01:03 was associated with severe ulcerative colitis requiring major operation, hospitalization, and systemic corticosteroid use compared with less severe disease. HLA-DRB1*01:03 has previously been linked to ulcerative colitis incidence. This study supports earlier, targeted genetic studies comparing patients with healthy controls reporting an association with total disease and severe disease requiring colectomy.
Corresponding Author: To contact the corresponding author, Marie Vibeke Vestergaard, MSc, email marievv@dcm.aau.dk.
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(doi:10.1001/jama.2024.20429)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Media advisory: This study is being presented at United European Gastroenterology Week 2024.
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Journal
JAMA