Researchers develop new implant to power healing after spinal cord injury

28 August 2024: A research team at RCSI University of Medicine and Health Sciences, Dublin has developed a new implant that conveys electrical signals and may have the potential to encourage nerve cell (neuron) repair after spinal cord injury.  

Details of the implant and how it performs in lab experiments have just been published in the journal Materials Today. 

“To date, it has been extremely difficult to promote the regrowth of neurons after spinal cord injury which is a major obstacle in the development of successful treatments for such debilitating injuries,” explains Professor Fergal O’Brien, Deputy Vice Chancelllor for Research and Innovation and Professor of Bioengineering and Regenerative Medicine at RCSI and Head of RCSI’s Tissue Engineering Research Group (TERG). “Our research here represents a promising new approach which may have potential for the treatment of spinal cord injuries.” 

Spinal cord injury is a devastating and often paralysing condition. One person suffers a spinal cord injury every week in Ireland, and there are over 2,300 individuals and families living with spinal cord injury across Ireland.  After injury, the long axonal projections of nerve cells are cut and “die-back” from the injury site, and at the same time a lesion or gap forms at the wound site that prevents their regrowth necessary to restore function.  

To address this complex problem, the research team at RCSI’s TERG and the SFI Advanced Materials and Bioengineering Research (AMBER) Centre at Trinity College Dublin developed an implantable, electroconductive 3D-printed scaffold that can be placed directly into the injury site, bridging the gap. 

Professor O’Brien, who is also Deputy Director of AMBER sees the implant as a new approach “Bridging the lesion with an electroconductive biomaterial designed to mimic the structure of the spinal cord, combined with the application of electrical stimulation, may help injured neurons regrow their axons and reconnect to restore function,” he said, adding that “No such platform exists to date.”  

When electrical stimulation is applied to the implant, it can convey that electrical signal to boost the regrowth of the injured axons. At the same time, the scaffolding and channels of the implant are designed to act as a bridge and direct the axons to grow back in the correct formation.  

When the researchers put the implant to the test in the lab, they saw promising results.  

“We could see that when we applied electrical stimulation for a week to neurons growing on this scaffold, they developed long healthy extensions called neurites. In the body, this kind of growth would be a key step towards repair and recovery after an injury,” said Liam Leahy, first author of the study and a PhD candidate at RCSI.  

The RCSI and AMBER researchers teamed up with the Irish Rugby Football Union Charitable Trust (IRFU-CT) on the project and brought together a spinal cord injury advisory group to oversee and guide the research. That group included clinicians, individuals living with spinal cord injury and Public and Patient Involvement (PPI) researchers. 

“This advisory group provided valuable insight into the realities of spinal cord injuries and potential treatment strategies,” says Leahy. Through regular meetings as well as laboratory visits, the advisory group helped guide the work from its inception to the current publication and led to two separate publications on the role of Public and Patient Involvement in preclinical research.”   

The implant project was supported by the Irish Rugby Football Union Charitable Trust, the Science Foundation Ireland Advanced Materials and Bioengineering Research (AMBER) Centre, the Irish Research Council and the research findings were recently presented at the TERMIS World Congress in Seattle, Washington, USA. 

ENDS 

About RCSI University of Medicine and Health Sciences 

RCSI University of Medicine and Health Sciences is ranked fifth in the world for its contribution to UN Sustainable Development Goal 3, Good Health and Well-being, in the Times Higher Education (THE) University Impact Rankings 2024.   

Founded in 1784 as the Royal College of Surgeons in Ireland with responsibility for training surgeons in Ireland, today RCSI is an innovative, not-for-profit, international university exclusively focused on driving improvements in human health worldwide through education, research and engagement. 

RCSI is among the top 300 universities worldwide in the World University Rankings (2024) and has been awarded Athena Swan Bronze accreditation for positive gender practice in higher education.

In 2026, RCSI will open a new public engagement space, dedicated to health and well-being, at 118 St Stephen’s Green in Dublin city centre. The space is designed to engage the public in dialogue about living longer, healthier and happier lives through dynamic events and exhibitions. Our aim is to bridge the gap between health sciences research, professional expertise, and public understanding, empowering people to make informed decisions about their health. 

Visit the RCSI MyHealth Expert Directory to find the details of our experts across a range of healthcare issues and concerns. Recognising their responsibility to share their knowledge and discoveries to empower people with information that leads them to better health, these clinicians and researchers are willing to engage with the media in their area of expertise.