Mankai reduces post-meal sugar levels in diabetics

BEER-SHEVA and TEL AVIV, Israel, August 28, 2024 – A pioneering clinical trial conducted at Sheba Medical Center, Tel Hashomer, and Ben-Gurion University of the Negev has demonstrated that consuming Mankai—a novel cultivated aquatic plant—after meals can significantly lower blood sugar levels in patients with diabetes. The study found that Mankai's impact on reducing blood sugar levels is comparable to that of some medications.

High blood sugar, especially after meals, poses significant health risks for individuals with type 2 diabetes. This condition is often worsened by insulin resistance, which reduces the effectiveness of insulin in muscles and the liver. Chronic high blood sugar can damage blood vessels, affect the peripheral nervous system, and increase the risk of severe complications such as heart attack, stroke, kidney failure, blindness, and reduced sensation in extremities.

Prof. Amir Tirosh from Sheba Medical Center, along with Dr. Gal Tsaban and Prof. Iris Shai from Ben-Gurion University, investigated the effects of Mankai on post-meal blood sugar levels in type 2 diabetes patients. Mankai is known for its high protein, dietary fiber, and antioxidant content. The study, published in Obesity, Diabetes, and Metabolism(https://doi.org/10.1111/dom.15840) earlier this month, found that drinking a Mankai beverage after dinner led to an approximate 20% reduction in post-meal blood sugar levels, lower peak sugar levels, and a faster return to baseline levels. This effect was observed in about two-thirds of the participants.

The trial involved 45 participants with diabetes and glycosylated hemoglobin (A1c) levels between 6.5% and 8.5%. Participants were randomly assigned to consume either a 300 ml Mankai drink or an equivalent volume of water after dinner for two weeks, followed by a switch in interventions for another two weeks. Blood sugar levels were monitored continuously using glucose sensors and standard laboratory tests throughout the study.

Mankai, which grows naturally in water and is now cultivated under controlled conditions, has shown promise in previous research for improving vascular and brain health, reducing abdominal and liver fat, and positively influencing the microbiome. Early studies also suggest that Mankai may help lower post-meal blood sugar levels even in individuals without diabetes.

Dr. Gal Tsaban remarked, “The study demonstrates that consuming Mankai after meals can lead to significant reductions in blood sugar levels. This finding introduces a promising new option for managing diabetes and reducing associated complications.”

Prof. Iris Shai added, “These results highlight the potential of Mankai as a valuable tool for diabetes management and warrant further investigation.”

Prof. Amir Tirosh concluded, “Nutrition plays a crucial role in both the development and management of diabetes. Incorporating Mankai into the diet can enhance blood sugar control and provide beneficial nutrients that support overall health.”

This work was supported by grants from the German Research Foundation (DFG), Israel Ministry of Health and Israel Ministry of Science and Technology.

Article authors: Gal Tsaban^1,2*†, Genya Aharon-Hananel^3*, Shiran Shalem³, Hila Zelicha¹, Anat Yaskolka Meir^1,4, Dafna Pachter¹, Dana Tamar Goldberg¹, Omer Kamer¹, Liav Alufer¹, Meir J Stampfer^5,6, Dong D. Wang⁶, Lu Qi⁵, Matthias Blüher⁷, Michael Stumvoll⁷, Frank B. Hu^5,6, Iris Shai^1,5,8†, Amir Tirosh^3†

¹ Ben-Gurion University of the Negev, Beersheva, Israel
² Soroka University Medical Center, Beersheva, Israel
³ Division of Endocrinology, Diabetes and Metabolism, Sheba Medical Center, Tel-HaShomer, Israel
⁴ Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA
⁵ Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA
⁶ Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA
⁷ Medical Department III – Endocrinology, Nephrology, Rheumatology and Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG) of the Helmholtz Center Munich at the University of Leipzig and University Hospital Leipzig, Leipzig, 04103, Germany
⁸ Faculty of Medicine, University of Leipzig