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“In our study, we postulated that these differences were driven by three common low-risk (LR) missense variants: p.I157T, p.S428F, and p.T476M, all of which have a BC odds ratio of <1.4.”
BUFFALO, NY- August 26, 2024 – A new editorial was published in Oncotarget's Volume 15 on July 10, 2024, entitled, “Genotype matters: Personalized screening recommendations for germline CHEK2 variants.”
Recognized as a moderate-risk gene, CHEK2—responsible for encoding the CHK2 protein, which plays a crucial role in the repair of DNA double-strand breaks—is associated with a 20–40% lifetime risk of breast cancer (BC) by age 85. While CHEK2 pathogenic variants (PVs) were previously linked to an increased risk of colorectal cancer (CRC), two recent studies have not observed this association.
In their recent work, researchers Adela Rodriguez Hernandez, Rochelle Scheib, Judy E. Garber, Huma Q. Rana and Brittany L. Bychkovsky from Dana-Farber Cancer Institute and Harvard Medical School in Boston, found that a CHEK2 PV does not increase the CRC risk compared with controls (odds ratio 0.62 (0.51–0.76), p < .001).
The cancer risks associated with CHEK2 PVs vary depending on the variant type, and risk management strategies should reflect this variability. The CHEK2 c.1100del is the most studied truncating variant and has been crucial to our understanding of the cancer phenotype. Cancer risks seem to be higher with truncating variants compared to missense variants.
“In our study, we postulated that these differences were driven by three common low-risk (LR) missense variants: p.I157T, p.S428F, and p.T476M, all of which have a BC odds ratio of <1.4.”
In summary, CHEK2 is recognized as a moderate-risk gene for breast cancer. Further large-scale, prospective studies are needed to clarify its potential associations with prostate, kidney, and thyroid cancers, as well as to establish appropriate screening measures.
Continue reading: DOI: https://doi.org/10.18632/oncotarget.28604
Correspondence to: Brittany L. Bychkovsky - brittany_bychkovsky@dfci.harvard.edu
Video short: https://www.youtube.com/watch?v=KYHCdGz8c3I
Keywords: CHEK2, pathogenic or likely pathogenic variants, germline
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Journal
Oncotarget
Method of Research
Commentary/editorial
Subject of Research
Not applicable
Article Title
Genotype matters: Personalized screening recommendations for germline CHEK2 variants
Article Publication Date
10-Jul-2024
COI Statement
JEG reports executive employment at Breast Cancer Research Foundation (self); consulting and/or scientific advisory board roles for The James P. Wilmot Foundation, Inc. (self); Earli Inc. (self); and fiduciary board role at the American Association for Cancer Research (self). All the other authors have no conflicts to report.