image: Fig. 1. Influences of treatments on skin hydration indexes, including water content (A) and Transepidermal water loss (TEWL) of volunteers (B) *: Intra-group significance difference, P <0.05;#:Inter-group significance difference, P < 0.05.
Credit: Shan Lu, et al
With aging, collagen and elastin in the skin decrease, leading to sagging, fine lines and deep wrinkles. These changes often arise from oxidative stress, inflammation, and changes in enzyme activities.
Collagen is the main structural protein of extracellular matrix of connective tissue, and has a positive role in healing, bone regeneration and anti-aging of skin. The active collagen tripeptides (CPs), such as Gly-Pro-Hyp (GPH) and Pro-Hyp (PH), have shown effectiveness in anti-skin aging. In particular, CPs and elastin peptides (EPs) supplements can repair wrinkles, accelerate collagen synthesis, and play an anti-aging effect. However, despite oligopeptide collagen, CP, and EP exhibiting skin soothing and anti-aging effect confirmed in other fields, their combination effects in anti-aging have rarely been investigated.
In a study published in the Volume 1, Issue 2 of Journal of Dermatologic Science and Cosmetic Technology, 70 volunteers were recruited with the aim to evaluate the effects of an orally administered collagen drink combining CP and EP on the skin health of young and middle-aged women.
“The participants were partitioned into two groups: one treated by collagen-rich drink (combination effects of different CP including tripeptide) and the other, as the placebo group,” shares the study’s lead author Shan Lu.
Compared to the placebo group, the collagen drink group showed significant improvements in skin hydration, transepidermal water loss, skin elasticity, dermal collagen content, pore size, wrinkle length, skin smoothness and skin roughness decrease.
“Further, mass spectrometry demonstrated a significant increase in collagen efficacy components, including blood pH and GPH levels,” adds Lu.
Overall, the study’s findings support the combined use of CP and EP as dietary supplements to effectively combat skin aging in the skin of young and middle-aged.
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Contact the author:
Yun Wang，Department of Dermatology, Shanghai Ninth People‘s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200125, China，wangyun1@live.cn
Tiantian Zhao，Sericulture & Agri-food Research Institute Guangdong Academy of Agricultural Sciences, Key Laboratory of Functional Foods, Ministry of Agriculture and Rural affairs, Guangdong Key Laboratory of Agricultural Products Processing, Guangzhou, Guangdong 510610, China，Department of Food Science, Rutgers University, New Brunswick, NJ 08901, United States，fettzhao1989@163.com
Guoxun Xiao，Wonderlab Innovation Centre for Healthcare, Shenzhen Porshealth Bioengineering Co, Ltd., Shenzhen 518116, China，shawn@wonderlab.top
The publisher KeAi was established by Elsevier and China Science Publishing & Media Ltd to unfold quality research globally. In 2013, our focus shifted to open access publishing. We now proudly publish more than 100 world-class, open access, English language journals, spanning all scientific disciplines. Many of these are titles we publish in partnership with prestigious societies and academic institutions, such as the National Natural Science Foundation of China (NSFC).
Journal
Journal of Dermatologic Science and Cosmetic Technology
Method of Research
Experimental study
Subject of Research
People
Article Title
Anti-skin aging effects and bioavailability of collagen tripeptide and elastin peptide formulations in young and middle-aged women
COI Statement
The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Author Silu Zhang, Shan Lu and Guoxun Xiao were employed by the company Shenzhen Porshealth Bioengineering Co.,Ltd. Author Jiayi Ni was employed by the company Sprim (China) Consulting Co. Ltd. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.