image: Oncotarget published the editorial, "How to deal with runaway metastatic disease?" on July 12, 2024
Credit: Impact Journals, LLC
BUFFALO, NY - August 7, 2024 – A new editorial paper was published in Oncotarget's Volume 15 on July 12, 2024, entitled, “How to deal with runaway metastatic disease?”
In this new editorial, Justine Paris and Guilhem Bousquet from Université Paris Cité, Université Sorbonne Paris Nord, and APHP, Hôpital Avicenne, Oncologie médical, discussed how their research team have shown that PROM2 is a predictive biomarker of distant metastases and shorter survival among patients with stage III melanomas.
More recently, in a large preclinical study using cancer cell lines and various mouse models of human melanomas, the researchers also demonstrated that the runaway metastatic process is closely linked to PROM2 overexpression, through the increase of epithelial-to-mesenchymal transition (EMT) marker expression and ferroptosis resistance.
“We report two critical findings: (i) these findings, initially observed in melanoma, have also been confirmed in renal and breast cancers; (ii) we successfully implemented an original in vivo model of metastatic runaway in order to mimic what occurs in patients.”
Continue reading: DOI: https://doi.org/10.18632/oncotarget.28609
Correspondence to: Guilhem Bousquet
Email: guilhem.bousquet@aphp.fr
Keywords: metastatic disease, PROM2, biomarker, tumor growth models
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Journal
Oncotarget
Method of Research
Commentary/editorial
Subject of Research
Not applicable
Article Title
How to deal with runaway metastatic disease?
Article Publication Date
12-Jul-2024
COI Statement
Authors have no conflicts of interest to declare.