image: Figure 3. Comparison of change in LTL over the 2-year follow-up according to osteoporosis. (A) Scatterplot showing the associations between baseline LTL and percentage change in LTL over a 2-year follow-up (the dotted line divides the study participants into quartile groups); (B) LOWESS curves showing the trend between baseline LTL and percentage change in LTL over a 2-year follow-up according to osteoporosis; (C) bar plot showing the percentage of osteoporosis after dividing the participants into quartile groups according to the LTL percentage change over the 2-year follow-up; (D) boxplots with jitters showing comparison of changes in LTL over the 2-year follow-up according to osteoporosis. LOWESS, locally weighted scatter plot smoothing; LTL, leukocyte telomere length.
Credit: 2024 Han et al.
“We sought to identify an association between osteoporosis and LTL shortening in an independent prospective cohort.”
BUFFALO, NY- August 5, 2024 – A new research paper was published on the cover of Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 14, entitled, “Association between osteoporosis and the rate of telomere shortening.”
A shorter leukocyte telomere length (LTL) is reported to be associated with age-related diseases, including osteoporosis. Many studies have tried identifying the association between LTL and osteoporosis, although it remains controversial.
In this current study, researchers Myung-Hoon Han , Hyuk Sung Kwon, Mina Hwang, Hyun-Hee Park, Jee Hyang Jeong, Kyung Won Park, Eun-Joo Kim, Soo Jin Yoon, Bora Yoon, Jae-Won Jang, Jin Yong Hong, Seong Hye Choi, and Seong-Ho Koh from Hanyang University Guri Hospital, Hanyang University Graduate School of Biomedical Science and Engineering, Ewha Womans University College of Medicine, Dong-A University College of Medicine, Pusan National University Hospital, Eulji University Hospital, Eulji University School of Medicine, Konyang University College of Medicine, Kangwon National University School of Medicine, Yonsei University Wonju College of Medicine, and Inha University College of Medicine, aimed to determine whether osteoporosis is independently associated with LTL shortening in a prospective longitudinal cohort.
“We compared the LTL values for each participant at baseline and over a 2-year follow-up period.”
Multivariable linear regression was conducted to identify whether osteoporosis is independently associated with the rate of telomere shortening. A total of 233 subjects (from 55 to 88 years) from the KBASE cohort were finally enrolled in the study.
Multivariable linear regression analysis indicated that only osteoporosis was independently associated with rapid LTL shortening over 2 years (B, -8.08; p = 0.038).
“We sought to identify an association between osteoporosis and LTL shortening in an independent prospective cohort.”
Read the full study: DOI: https://doi.org/10.18632/aging.206034
Corresponding Authors: Seong Hye Choi - seonghye@inha.ac.kr, and Seong-Ho Koh - ksh213@hanyang.ac.kr
Keywords: aging, leukocyte telomere length, osteoporosis, interleukin-6, prospective cohort
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About Aging-US:
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Journal
Aging-US
Method of Research
News article
Subject of Research
People
Article Title
Association between osteoporosis and the rate of telomere shortening
Article Publication Date
25-Jul-2024
COI Statement
There are no conflicts of interest to be declared.