Unraveling the DNA mystique of Saposhnikovia divaricata: New horizons in herbal medicine

In a pioneering study, scientists have decoded the genetic blueprint of Saposhnikovia divaricata, a traditional medicinal herb. The research provides a detailed genome sequence, shedding light on the plant’s evolutionary adaptations and the genetic foundations of its therapeutic benefits. Identifying crucial genetic markers, the study paves the way for enhancing the medicinal efficacy of this age-old herbal remedy through targeted genomic breeding strategies.

Despite its revered status in traditional Chinese medicine, Saposhnikovia divaricata has not been thoroughly studied genetically. This herb, used to treat rheumatism and skin conditions, holds untapped potential due to unknown genetic and metabolic profiles. The recent study aims to fill this gap by mapping its genome, offering insights that could improve its medicinal properties through advanced breeding and biotechnological methods, potentially leading to superior therapeutic applications.

Published (DOI: 10.1093/hr/uhae105) in April 2024 in Horticulture Research, this collaborative research involved Jilin Agricultural University and various other institutions, including international partners from the University of British Columbia. Leveraging cutting-edge sequencing technologies, the study delivers a chromosome-level genome assembly, providing a deeper understanding of the plant’s intricate genetic structure and its adaptation strategies.

The genomic analysis of Saposhnikovia divaricata uncovered a genome size of 2.07 Gb, rich in repetitive sequences and marked by a notable whole-genome duplication. These characteristics indicate a vast genetic diversity and adaptability, essential for its survival and medicinal effectiveness. The study pinpointed several gene families crucial for synthesizing key pharmacological agents like flavonoids and plant hormones. Furthermore, comparative genomic studies with related species illuminate unique evolutionary paths and gene expansions that enhance its distinct pharmacological properties, crucial for future efforts to boost the plant’s medicinal value.

Dr. Zhong-Ming Han, the study's lead author, stated, “This genome assembly opens new paths for the biotechnological use of Saposhnikovia divaricata. Understanding its genetic and metabolic pathways is foundational for developing enhanced varieties with greater therapeutic potential.”

The research holds significant implications beyond traditional applications, opening doors to pharmaceutical innovations. With an improved understanding of the genetic elements driving its pharmacological effects, there is potential for creating more effective medicinal derivatives from Saposhnikovia divaricata, merging ancient remedies with modern medical technology.

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References

DOI

10.1093/hr/uhae105

Original Source URL

https://doi.org/10.1093/hr/uhae105

Funding information

This research was supported by a Chinese Key Research and Development Project grant (2019YFC1710700) awarded to L.-M.Y., Promotion Demonstration Project of Forestry Science and Technology of China (JLT2024–30) awarded to Z.-M.H., Jilin Agricultural University high level researcher grant (JLAUHLRG20102006) awarded to J.Z.

About Horticulture Research

Horticulture Research is an open access journal of Nanjing Agricultural University and ranked number one in the Horticulture category of the Journal Citation Reports ™ from Clarivate, 2022. The journal is committed to publishing original research articles, reviews, perspectives, comments, correspondence articles and letters to the editor related to all major horticultural plants and disciplines, including biotechnology, breeding, cellular and molecular biology, evolution, genetics, inter-species interactions, physiology, and the origination and domestication of crops.