Neural mechanism of encoding familiar faces

Tsukuba, Japan—People experience a sense of familiarity from those who provide them with food and care on a daily basis. For children and pets, remembering the faces of such individuals is crucial for survival. The basal ganglia, specifically the striatum tail, located in the deep region of the brain, plays a critical role in associating objects with their value through long-term experience. However, insight into how this mechanism operates in complex social situations, such as daily life, which is different from laboratory environments, remains unclear.

In this study, researchers presented monkeys with images of familiar and unfamiliar faces and recorded the neural activity from the tail part of the striatum . The neuronal mechanism used for storing the faces of familiar individuals in the brain was found to be the same as that used for remembering the value of objects.

The researchers showed the monkeys photographs of people who had cared for them daily for over a year as well as photographs of strangers, and recorded the neural activity from the tail part of the striatum . The caudate nucleus responded strongly to familiar faces but weakly to unfamiliar ones. Moreover, the same neurons responded similarly to the varying values of objects. Considering that these neurons are also involved in rapid identification of valuable objects, they may be important in enabling children and pets to quickly identify familiar individuals.

These findings elucidate the mechanisms through which the brain forms and maintains social relationship. They are also useful in understanding and treating disorders caused by damage to the basal ganglia, including the tail part of the striatum, such as Parkinson's disease.

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This research was supported by the Intramural Research Program at the National Institutes of Health, National Eye Institute; the Japan Science and Technology Agency, PRESTO (JPMJPR21S4); MEXT/JSPS (23H02780 and 23H04329); and Takeda Science Foundation.

_{Original Paper}

Title of original paper:
Neuronal response of the primate striatum tail to face of socially familiar persons

Journal:
iScience

DOI:
10.1016/j.isci.2024.110043

_{Correspondence}

Assistant Professor KUNIMATSU, Jun
Institute of Medicine, University of Tsukuba

Program-Specific Associate Professor AMITA, Hidetoshi
Center for the Evolutionary Origins of Human Behavior, Kyoto University

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Institute of Medicine