About The Study: This randomized clinical trial of Chinese adults with overweight or obesity and with early type 2 diabetes found that an intermittent fasting plan consisting of two nonconsecutive fasting days and five days of habitual intake per week and meal replacement diet (5:2 MR) could improve glycemic outcomes and weight loss in the short term compared with metformin or empagliflozin, making it a promising initial intervention and early management for type 2 diabetes.
Corresponding Author: To contact the corresponding author, Lixin Guo, M.D., email glx1218@163.com.
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(doi:10.1001/jamanetworkopen.2024.16786)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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